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Titolo:
HIGH-INCIDENCE OF CENTRAL-NERVOUS-SYSTEM MALFORMATIONS ASSOCIATED WITH MARKED PARENTAL CONSANGUINITY IN AN ISRAELI ARAB COMMUNITY
Autore:
JABER L; MERLOB P; SHOHAT M;
Indirizzi:
BEILINSON MED CTR,FELSENSTEIN RES INST,DEPT MED GENET NEONATOL & PEDIAT IL-49100 PETAH TIQWA ISRAEL BEILINSON MED CTR,FELSENSTEIN RES INST,DEPT MED GENET NEONATOL & PEDIAT IL-49100 PETAH TIQWA ISRAEL TEL AVIV UNIV,SACKLER SCH MED IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Biomedicine & pharmacotherapy
fascicolo: 8-9, volume: 48, anno: 1994,
pagine: 351 - 354
SICI:
0753-3322(1994)48:8-9<351:HOCMAW>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Keywords:
MAJOR MALFORMATIONS; CONSANGUINITY; FOUNDER EFFECT; CENTRAL NERVOUS SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
L. Jaber et al., "HIGH-INCIDENCE OF CENTRAL-NERVOUS-SYSTEM MALFORMATIONS ASSOCIATED WITH MARKED PARENTAL CONSANGUINITY IN AN ISRAELI ARAB COMMUNITY", Biomedicine & pharmacotherapy, 48(8-9), 1994, pp. 351-354

Abstract

It is common among Israeli Arabs who live in villages to prefer consanguineous marriages, particularly among first cousins. In addition, such villages are populated by a few (< 20) original families, and inter-family/inter-village marriages are infrequent. The purpose of this study was to examine the incidence of congenital malformation of the central nervous system associated with such ''consanguinity'' in Taibe, alarge Arab village, 30 km from Tel Aviv. Six hundred and ten familieswere prospectively ascertained through infants who were routinely seen in the local ''Well Baby Clinics''. A significant increase in the incidence of major malformations was noted in relation to the closeness of the parental relationship. For the index cases group, the prevalence of individuals with major malformations was 5.8% in the product of inter-village marriages, 8.3% in the intra-village non-related matings,15.1% in the distant consanguineous group, and up to 15.8% in the progeny of first-cousin marriages (P < 0.001). Malformations of the central nervous system consisted of 1/3 to 1/2 of the total malformations in the consanguineous groups versus less than 1/5 in the non-consanguineous groups. The study demonstrates a marked high rate of consanguineous marriages, the effect of which leads to a marked increase in major malformations and especially those of the central nervous system. Thisrequires a unique genetic counseling approach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 10:36:00