Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FACTORS DETERMINING THE LONG-TERM OUTCOME OF SURGERY FOR ACROMEGALY
Autore:
OSMAN IA; JAMES RA; CHATTERJEE S; MATHIAS D; KENDALLTAYLOR P;
Indirizzi:
UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT MED,ENDOCRINE UNIT NEWCASTLE TYNE NE2 4HH TYNE & WEAR ENGLAND UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT MED,ENDOCRINE UNIT NEWCASTLE TYNE NE2 4HH TYNE & WEAR ENGLAND FREEMAN RD HOSP,DEPT EAR NOSE & THROAT NEWCASTLE TYNE NE7 7DN TYNE & WEAR ENGLAND
Titolo Testata:
Quarterly Journal of Medicine
fascicolo: 10, volume: 87, anno: 1994,
pagine: 617 - 623
SICI:
1460-2725(1994)87:10<617:FDTLOO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANS-SPHENOIDAL SURGERY; GROWTH-HORMONE RESPONSE; PITUITARY SURGERY; MICROSURGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
I.A. Osman et al., "FACTORS DETERMINING THE LONG-TERM OUTCOME OF SURGERY FOR ACROMEGALY", Quarterly Journal of Medicine, 87(10), 1994, pp. 617-623

Abstract

Seventy-nine patients with acromegaly were investigated before and after transsphenoidal adenomectomy, to determine the immediate and late outcome, the pre-operative features associated with a good result, andthe accuracy of post-operative testing in predicting outcome. pre-operative evaluation included basal growth hormone (GH), GH response to oral glucose tolerance test (OGTT), GH response to thyrotrophin-releasing hormone (TRH), tests of pituitary reserve, and pituitary scanning to assess tumour size. A few weeks after surgery, these tests were repeated. The patients were recalled for late assessment 1-13 years (median 86 months) after the operation, At the immediate postoperative testing, minimum GH after oral glucose was less than or equal to 2 mU/l in 48.7%, <5 mU/l in 76.3% and <10 mU/l in 84.2%, Only 12 patients had GH>10 mU/l. Basal GH was less than or equal to 2 mU/l in 21%, <5 in 59.2%, <10 in 73.6% and <20 in 90.8%. A minimum GH of less than or equal to 2 mU/l during an OGTT was achieved in 67.4% of patients with intrasellar tumours, compared with 27.3% with extrasellar tumours. Basal GH and post-glucose GH correlated with the late outcome. GH response to TRH showed no correlation with outcome. ICF-1, which could not be assessed in detail, correlated with GH but was not a reliable indicator of outcome. Transsphenoidal adenomectomy is thus a very satisfactory treatment for acromegaly. Postoperative levels of basal growth hormone <5 mU/l and post-glucose GH less than or equal to 2 mU/l can be regarded as a biochemical cure. Postoperative radiotherapy is not required in patients who achieve a good result. The preoperative factors which significantly influenced the final outcome were basal GH, post-glucose minimum GH, tumour size and impaired pituitary reserve.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 08:59:38