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Titolo:
VENTILATION-PERFUSION RELATIONSHIPS IN PRETERM INFANTS AFTER SURFACTANT TREATMENT
Autore:
BOWEN W; MARTIN CR; KRAUSS AN; AULD PAM;
Indirizzi:
NEW YORK HOSP,CORNELL MED CTR,DEPT PEDIAT,CTR PERINATOL,525 E 68TH STNEW YORK NY 10021 NEW YORK HOSP,CORNELL MED CTR,DEPT PEDIAT,CTR PERINATOL NEW YORK NY 10021
Titolo Testata:
Pediatric pulmonology
fascicolo: 3, volume: 18, anno: 1994,
pagine: 155 - 162
SICI:
8755-6863(1994)18:3<155:VRIPIA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYALINE-MEMBRANE DISEASE; RESPIRATORY-DISTRESS SYNDROME; PLACEBO-CONTROLLED TRIAL; BIRTH-WEIGHT INFANTS; SYNTHETIC SURFACTANT; CLINICAL-TRIAL; PREMATURE-INFANTS; GAS-EXCHANGE; LUNG-VOLUME; REPLACEMENT;
Keywords:
ARTERIAL-ALVEOLAR DIFFERENCES; P-O2; P-CO2; P-N2 HYALINE MEMBRANE DISEASE; RESPONDERS; NONRESPONDERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
W. Bowen et al., "VENTILATION-PERFUSION RELATIONSHIPS IN PRETERM INFANTS AFTER SURFACTANT TREATMENT", Pediatric pulmonology, 18(3), 1994, pp. 155-162

Abstract

Arterial-alveolar partial pressure differences for oxygen, carbon dioxide, and nitrogen were measured before and after surfactant replacement therapy on 15 occasions in 14 ventilator-dependent preterm infants with hyaline membrane disease (HMD). Eight treatments resulted in a significant improvement in arterial partial pressure of oxygen (P-aO2) 2hr after treatment; 7 did not. Neither group showed any significant change in arterial-alveolar partial pressure differences for oxygen, nitrogen, and carbon dioxide. This observation suggests that if surfactant replacement therapy produces an improvement in P-aO2 it does so by recruitment of atelectatic alveoli with a balanced ventilation/perfusion ratio rather than by redistribution of ventilation within already ventilated alveoli. (C) 1994 Wiley-Liss, Inc.

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Documento generato il 02/04/20 alle ore 02:54:28