Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TELOMERE LENGTH VARIATION IN NORMAL AND MALIGNANT HUMAN TISSUES
Autore:
SCHMITT H; BLIN N; ZANKL H; SCHERTHAN H;
Indirizzi:
UNIV TUBINGEN,DIV MOLEC GENET,WILHELMSTR 27 D-72074 TUBINGEN GERMANY UNIV KAISERSLAUTERN,DIV HUMAN GENET & MOLEC BIOL W-6750 KAISERSLAUTERN GERMANY
Titolo Testata:
Genes, chromosomes & cancer
fascicolo: 3, volume: 11, anno: 1994,
pagine: 171 - 177
SICI:
1045-2257(1994)11:3<171:TLVINA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL TUMORS; DNA; REPEATS; ASSOCIATIONS; CHROMOSOMES; HYBRIDIZATION; LYMPHOCYTES; (TTAGGG)N; SEQUENCE; INSITU;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
H. Schmitt et al., "TELOMERE LENGTH VARIATION IN NORMAL AND MALIGNANT HUMAN TISSUES", Genes, chromosomes & cancer, 11(3), 1994, pp. 171-177

Abstract

Tissue and tumor specific length variation of telomere (TTAGGG)(n) repeats was studied in DNAs from various normal and malignant tissues. DNA was isolated from bone marrow and blood cells, malignant tissues, and established tumor cell lines. Nonisotopic Southern hybridization revealed a reduction of telomere repeat arrays in 14 of the 35 tumors analyzed. However, other cases (60%) showed no reduction, or even an increase, in telomeric length. Our finding of elongated telomere stretches in several tumors of different origin compared with normal tissue isin contrast to previous reports describing a general shortening of terminal repeat length in colorectal cancer and neuroblastoma. We tentatively conclude that there is no general tendency to telomere reductionin malignant (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:33:03