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Titolo:
COMPARISON BETWEEN THE EFFECT OF L-PROPIONYLCARNITINE, L-ACETYLCARNITINE AND NITROGLYCERIN IN CHRONIC PERIPHERAL ARTERIAL-DISEASE - A HEMODYNAMIC DOUBLE-BLIND ECHO-DOPPLER STUDY
Autore:
SABBA C; BERARDI E; ANTONICA G; FERRAIOLI G; BUONAMICO P; GODI L; BREVETTI G; ALBANO O;
Indirizzi:
UNIV BARI,IST CLIN MED 1,PIAZZA GIULIO CESARE 11 I-70124 BARI ITALY
Titolo Testata:
European heart journal
fascicolo: 10, volume: 15, anno: 1994,
pagine: 1348 - 1352
SICI:
0195-668X(1994)15:10<1348:CBTEOL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-DISEASE; L-CARNITINE; INTERMITTENT CLAUDICATION; BLOOD-FLOW; CROSSOVER; FAILURE;
Keywords:
L-PROPIONYLCARNITINE; L-CARNITINE; PERIPHERAL VASCULAR DISEASE; WALKING CAPACITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
C. Sabba et al., "COMPARISON BETWEEN THE EFFECT OF L-PROPIONYLCARNITINE, L-ACETYLCARNITINE AND NITROGLYCERIN IN CHRONIC PERIPHERAL ARTERIAL-DISEASE - A HEMODYNAMIC DOUBLE-BLIND ECHO-DOPPLER STUDY", European heart journal, 15(10), 1994, pp. 1348-1352

Abstract

The haemodynamic effects on the peripheral vascular bed of L-acetylcarnitine, L-propionylcarnitine, and nitroglycerin were tested by echo-Doppler in a double blind cross-over study. Eleven male patients suffering from peripheral arterial obliterative disease (PAOD) in the secondstage of Fontaine's classification, and 11 matched control subjects were enrolled in the study. Each subject received one of three different treatments on each day of the study in a different order following arandom assignment. The treatments were either 30 mg x kg of L-acetylcarnitine (LAC) or 30 mg x kg of L-propionylcarnitine (LPC) or nitroglycerin (NTG) 1.25 mg given as a single i.v. bolus injected over 3 min. Echo-Doppler measurements of blood flow velocity, and cross-sectional area of the femoral artery were performed at baseline and 10, 20, and 30 min after injection the drugs. Pulsatility Index (an index derived from the blood flow velocity and related to vascular resistance: PI = Vmax - Vmin/Vmean) was also obtained each time. Results were analysed using a Student's t-test for paired data. L-acetylcarnitine and L-propionylcarnitine showed no haemodynamic effects in either group of subjects (controls and PAOD patients) whether blood flow or vascular resistance was considered. There were haemodynamic changes ( a decrease in blood flow velocity and an increase in arterial systemic resistance) only after NTG administration. The changes were more evident in controlsthan in PAOD patients. Femoral artery cross-sectional area showed no statistically significant effect as regards treatment. In conclusion, echo-Doppler flowmetry correctly assessed haemodynamic changes determined by the administration of NTG, whereas no changes were observed after LAC or LPC injection. Improvements in walking capacity after administration of these drugs could ony be related to metabolic effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:12:21