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Titolo:
ANTIGENICITY OF THE OLIGOSACCHARIDE MOIETY OF THE JAPANESE CEDAR (CRYPTOMERIA-JAPONICA) POLLEN ALLERGEN, CRY-J-I
Autore:
HIJIKATA A; MATSUMOTO I; KOJIMA K; OGAWA H;
Indirizzi:
OCHANOMIZU UNIV,FAC SCI,DEPT CHEM TOKYO 112 JAPAN OCHANOMIZU UNIV,FAC SCI,DEPT CHEM TOKYO 112 JAPAN
Titolo Testata:
International archives of allergy and immunology
fascicolo: 2, volume: 105, anno: 1994,
pagine: 198 - 202
SICI:
1018-2438(1994)105:2<198:AOTOMO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUGI BASIC-PROTEIN; CARBOHYDRATE MOIETY; MONOCLONAL-ANTIBODIES; CROSS-REACTIVITY; ANTISERUM; GLYCOPROTEINS; EPITOPES; LECTINS; GLYCANS; IGE;
Keywords:
CARBOHYDRATE; CRY J I, ANTIGENICITY; EPITOPE; OLIGOSACCHARIDE; POLLEN ALLERGEN;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A. Hijikata et al., "ANTIGENICITY OF THE OLIGOSACCHARIDE MOIETY OF THE JAPANESE CEDAR (CRYPTOMERIA-JAPONICA) POLLEN ALLERGEN, CRY-J-I", International archives of allergy and immunology, 105(2), 1994, pp. 198-202

Abstract

Cryj I, a major allergenic glycoprotein of Cryptomeria japonica (Japanese cedar, Sugi), is the most commom pollen allergen in Japan. Carbohydrate analysis and lectin staining indicated that Cryj I possesses the fucose/xylose-containing N-linked oligosaccharide which previously has been found in some plant gly- coproteins. Rabbit polyclonal anti-Cryj IIgG antibodies were found to be highly cross-reactive with two other plant glycoproteins which have the same type of oligosaccharides, and the cross-reactivities were completely abolished on chemical deglycosylation of the glycoproteins. Enzyme-linked immunosorbent assay inhibition showed that the majority (up to 70%) of the anti-Cryj I rabbit IgG antibodies recognized the oligosaccharide moiety of Cryj I. The carbohydrate epitopes were found to be only partially involved in the binding of specific IgE antibodies from a pool of human patient sera.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:03:36