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Titolo:
GLIAL DOMAINS AND AXONAL REORDERING IN THE CHIASMATIC REGION OF THE DEVELOPING FERRET
Autore:
REESE BE; MAYNARD TM; HOCKING DR;
Indirizzi:
UNIV CALIF SANTA BARBARA,NEUROSCI RES INST SANTA BARBARA CA 93106 UNIV CALIF SANTA BARBARA,DEPT PSYCHOL SANTA BARBARA CA 93106
Titolo Testata:
Journal of comparative neurology
fascicolo: 2, volume: 349, anno: 1994,
pagine: 303 - 324
SICI:
0021-9967(1994)349:2<303:GDAARI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING CEREBRAL-CORTEX; FIBRILLARY ACIDIC PROTEIN; MAMMALIAN OPTIC CHIASM; FIBER DIAMETER CLASSES; RADIAL GLIA; RETINAL AXONS; GROWTH CONES; SPINAL-CORD; NERVE; TRACT;
Keywords:
VIMENTIN; RADIAL GLIAL CELL; CHRONOTOPY; RETINOTOPY; DECUSSATION PATTERN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
B.E. Reese et al., "GLIAL DOMAINS AND AXONAL REORDERING IN THE CHIASMATIC REGION OF THE DEVELOPING FERRET", Journal of comparative neurology, 349(2), 1994, pp. 303-324

Abstract

This study has examined the developing glial architecture of the optic pathway and has related this to the changing organization of the constituent axons. Immunocytochemistry was used to reveal the distribution of glial profiles, and DiI was used to label either radial glial profiles or optic axons. Electron microscopy was used to determine the distribution of glial profiles, axons, growth cones, and wrists at different locations along the pathway. Three different glial boundaries were defined: Two of these are revealed as changes in the distribution ofvimentin-immunoreactive profiles occurring in the prechiasmatic opticnerve and at the threshold of the optic tract, respectively, and one by the presence of glial fibrillary acidic protein (GFAP)-immunoreactive profiles at the chiasmatic midline. The latter, midline boundary may be related to the segregation of nasal from temporal optic axons. The boundary at the threshold of the optic tract coincides with the segregation of dorsal from ventral optic axons that emerges at this location in the pathway. The segregation of old from young optic axons is shown to occur only gradually along the pathway. Glial profiles are mostfrequent in the deeper parts of the tract, coursing parallel to the optic axons and orthogonal to their usual radial axis. These are suggested to arise from later-growing radial glial fibers that are diverted to grow amongst the older optic axons. Those glial profiles may subsequently impede axonal invasion, thus creating the chronotopic reordering by forcing the later-arriving axons to accumulate superficially. (C)1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 07:12:20