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Titolo:
EVENING PRIMROSE OIL REDUCES URINARY CALCIUM EXCRETION IN BOTH NORMALAND HYPERCALCIURIC RATS
Autore:
TULLOCH I; SMELLIE WSA; BUCK AC;
Indirizzi:
GLASGOW ROYAL INFIRM,DEPT UROL,16 ALEXANDRA PARADE GLASGOW G31 2ER LANARK SCOTLAND GLASGOW ROYAL INFIRM,DEPT UROL GLASGOW G31 2ER LANARK SCOTLAND GLASGOW ROYAL INFIRM,DEPT RENAL MED GLASGOW G31 2ER LANARK SCOTLAND GLASGOW ROYAL INFIRM,DEPT RENAL MED GLASGOW G31 2ER LANARK SCOTLAND
Titolo Testata:
Urological research
fascicolo: 4, volume: 22, anno: 1994,
pagine: 227 - 230
SICI:
0300-5623(1994)22:4<227:EPORUC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINOLENIC ACID; FATTY-ACIDS; IDIOPATHIC HYPERCALCIURIA; GLOMERULAR HEMODYNAMICS; RENAL PROSTAGLANDINS; ARACHIDONIC-ACID; UROLITHIASIS; GLUCOSE; LIPIDS; N-3;
Keywords:
EVENING PRIMROSE OIL; URINARY CALCIUM EXCRETION; STREPTOZOTOCIN-INDUCED DIABETES; GAMMA-LINOLENIC ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
I. Tulloch et al., "EVENING PRIMROSE OIL REDUCES URINARY CALCIUM EXCRETION IN BOTH NORMALAND HYPERCALCIURIC RATS", Urological research, 22(4), 1994, pp. 227-230

Abstract

Hypercalciuria is an important risk factor in the aetiology of idiopathic urolithiasis and many treatment modalities in clinical practice are directed towards reducing urinary calcium excreation. There are no natural animal models of hypercalciuria, such as the spontaneous hypertensive rat; however, the streptozotocin-diabetic rat is accepted as agood model for studies of disordered renal function associated with diabetes mellitus. Hypercalciuria is a prominent feature of the streptozotocin-diabetic rat and the model was, therefore, used to study the influence of evening primrose oil on urinary clacium excretion. Twenty rats divided into two groups of ten rats each were maintained on either normal rat chow (group 1) or primrose oil enriched diet (group 2) for 10 weeks. At 4 weeks both groups of rats were made diabetic with streptozotocin. Urine calcium measurements were serially performed beforecommencement of the diet, during the pre-streptozotocin (pre-diabetic) phase and during the post streptozotocin (diabetic) phase. The urinecalcium excretion was significantly less in the primrose oil fed animals during both the pre-diabetic phase and the diabetic phase comparedwith the rats on the normal rat chow. These results indicate that evening primrose oil, a rich source of gamma-linolenic acid, helps to reduce urine calcium excretion in normal animals as well as in the hypercalciuric streptozotocin-diabetic rat. Dietary modifications with long-chain omega-6 and omega-3 fatty acids might be a useful adjunct in thetreatment of idiopathic hypercalciuric urolithiasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:15:48