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Titolo:
INFLUENCE OF A CA2-8644, ON THE ANTICONVULSANT ACTIVITY OF NMDA AND NON-NMDA RECEPTOR ANTAGONISTS( CHANNEL AGONIST, BAY K)
Autore:
CZUCZWAR SJ; GASIOR M; TURSKI WA; KLEINROK Z;
Indirizzi:
MARIE CURIE SKLODOWSKA UNIV,DEPT PHARMACOL & TOXICOL,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 264, anno: 1994,
pagine: 103 - 106
SICI:
0014-2999(1994)264:1<103:IOACOT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMON ANTIEPILEPTIC DRUGS; MICE; NITRENDIPINE; CONVULSIONS; BLOCKERS; SEIZURES;
Keywords:
AMPA RECEPTOR ANTAGONIST; NMDA RECEPTOR ANTAGONIST; BAY K-8644; SEIZURE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Czuczwar et al., "INFLUENCE OF A CA2-8644, ON THE ANTICONVULSANT ACTIVITY OF NMDA AND NON-NMDA RECEPTOR ANTAGONISTS( CHANNEL AGONIST, BAY K)", European journal of pharmacology, 264(1), 1994, pp. 103-106

Abstract

Bay k-8644 (2-trifluoro-methylphenyl)-pyridine-5-carboxylate) (a Ca2channel agonist of the dihydropyridine class) at 5 mg/kg (s.c.) impaired the anticonvulsant activities of two competitive NMDA receptor antagonists, CGP 37849 (D,L-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid) and D-CPP-ene (2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonicacid) (given i.p.), against electroconvulsions. In contrast, the Ca2channel agonist did not affect the protection afforded by the AMPA receptor antagonists, NBQX -dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline) and GYKI 52466 -4-methyl-7,8-methylendioxy-5-2,3-benzodiazepine), or by a non-competitive NMDA receptor antagonist, MK-801 (dizocilpine), all being injected i.p. It may be concluded that the anticonvulsive activity of competitive NMDA receptor antagonists can be impaired byCa2+ ion influx.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:27:58