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Titolo:
MULTIVARIATE CLUSTER-ANALYSIS OF DYNAMIC I-123 IODOBENZAMIDE SPET DOPAMINE D-2 RECEPTOR IMAGES IN SCHIZOPHRENIA
Autore:
ACTON PD; PILOWSKY LS; COSTA DC; ELL PJ;
Indirizzi:
UNIV COLL LONDON,SCH MED,INST NUCL MED,MORTIMER ST LONDON W1N 8AA ENGLAND INST PSYCHIAT LONDON ENGLAND
Titolo Testata:
European journal of nuclear medicine
fascicolo: 2, volume: 24, anno: 1997,
pagine: 111 - 118
SICI:
0340-6997(1997)24:2<111:MCODII>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRINCIPAL COMPONENT ANALYSIS; HUMAN-BRAIN; I-123 IBZM; EMISSION TOMOGRAPHY; PET;
Keywords:
CLUSTER ANALYSIS; MULTIVARIATE STATISTICS; DOPAMINE D-2 RECEPTORS; IMAGE SEGMENTATION; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
P.D. Acton et al., "MULTIVARIATE CLUSTER-ANALYSIS OF DYNAMIC I-123 IODOBENZAMIDE SPET DOPAMINE D-2 RECEPTOR IMAGES IN SCHIZOPHRENIA", European journal of nuclear medicine, 24(2), 1997, pp. 111-118

Abstract

This paper describes the application of a multivariate statistical technique to investigate striatal dopamine D-2 receptor concentrations measured by iodine-123 iodobenzamide (I-123-IBZM) single-photon emission tomography (SPET). This technique enables the automatic segmentationof dynamic nuclear medicine images based on the underlying time-activity curves present in the data; Once the time-activity curves have been extracted, each pixel can be mapped back on to the underlying distribution, considerably reducing image noise. Cluster analysis has been verified using computer simulations and phantom studies. The technique has been applied to SPET images of dopamine D-2 receptors in a total of 20 healthy and 20 schizophrenic volunteers (22 male, 18 female), using the ligand I-123-IBZM. Following automatic image segmentation, the concentration of striatal dopamine D-2 receptors shows a significant left-sided asymmetry in male schizophrenics compared with male controls. The mean left-minus-right laterality index for controls is -1.52 (95% CI -3.72-0.66) and for patients 4.04 (95% CI 1.07-7.01). Analysis ofvariance shows a case-by-sex-by-side interaction, with F=10.01, P=0.005. We can now demonstrate that the previously observed male sex-specific D-2 receptor asymmetry in schizophrenia, which had failed to attain statistical significance, is valid. Cluster analysis of dynamic nuclear medicine studies provides a powerful tool for automatic segmentation and noise reduction of the images, removing much of the subjectivity inherent in region-of-interest analysis. The observed striatal D-2 asymmetry could reflect long hypothesized disruptions in dopamine-rich cortico-striatal-limbic circuits in schizophrenic males.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:41:00