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Titolo:
STRUCTURE-ACTIVITY STUDIES ON 2-ARYL-4H-3,1-BENZOXAZIN-4-ONES
Autore:
HADFIELD JA; PAVLIDIS VH; MCGOWN AT; WHITWORTH C; PERRY PJ; FOX BW;
Indirizzi:
CHRISTIE HOSP & HOLT RADIUM INST,PATERSON INST CANC RES,CRC,DEPT EXPTL CHEMOTHERAPY MANCHESTER M20 9BX LANCS ENGLAND DE MONTFORT UNIV LEICESTER,SCH APPL PHYS SCI LEICESTER LE1 9BH LEICS ENGLAND
Titolo Testata:
Anti-cancer drugs
fascicolo: 5, volume: 5, anno: 1994,
pagine: 533 - 538
SICI:
0959-4973(1994)5:5<533:SSO2>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITORS; ELASTASE; DESIGN;
Keywords:
ANTITUMOR; 2-ARYL-4H-3,1-BENZOXAZIN-4-ONES; FLOW CYTOMETRY; MOLECULAR MODELING; ELASTASE INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Hadfield et al., "STRUCTURE-ACTIVITY STUDIES ON 2-ARYL-4H-3,1-BENZOXAZIN-4-ONES", Anti-cancer drugs, 5(5), 1994, pp. 533-538

Abstract

Eight benzoxazin-4-ones related in structure to NSC 341964 (1) have been tested for cytotoxicity in two different cell systems. Two of the benzoxazin-4-ones (3 and 10) showed good cytotoxicity (ID50 = 9.9 and 8.9 mu M) in P388 cells. The nitrobenzoxazin-4-one (10) caused a significant alteration in cell cycle distribution when administered to P388cells and was an inhibitor of porcine pancreatic elastase. Structure-activity relationships are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:11:21