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Titolo:
I-123 IBZM SPECT - RECONSTRUCTION METHODOLOGY AND RESULTS IN PARKINSONISM AND DYSTONIA
Autore:
BERDING G; GRATZ KF; KOLBE H; MEYER GJ; DENGLER R; KNOOP BO; HUNDESHAGEN H;
Indirizzi:
HANNOVER MED SCH,NUKL & SPEZIELLE BIOPHYS ABT,KONSTANTY GUTSCHOW STR 8 D-30623 HANNOVER GERMANY HANNOVER MED SCH,NEUROL KLIN KLIN NEUROPHYSIOL D-30623 HANNOVER GERMANY HANNOVER MED SCH,NUKL TECH & STRAHLEN ABT D-30623 HANNOVER GERMANY
Titolo Testata:
Nuklearmedizin
fascicolo: 5, volume: 33, anno: 1994,
pagine: 194 - 199
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; D-2 DOPAMINE-RECEPTORS; EMISSION TOMOGRAPHY; WILSONS-DISEASE; BRAIN; IBZM; IODINE-123-IBZM; HUMANS; CAMERA; SYSTEM;
Keywords:
I-123-IBZM; SPECT; RECONSTRUCTION; PARKINSONISM; DYSTONIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
G. Berding et al., "I-123 IBZM SPECT - RECONSTRUCTION METHODOLOGY AND RESULTS IN PARKINSONISM AND DYSTONIA", Nuklearmedizin, 33(5), 1994, pp. 194-199

Abstract

In 58 patients with Parkinsonism or dystonia striatal dopamine D2 receptors were investigated using I-123-iodobenzamide (I-123-IBZM) single-photon emission computed tomography (SPECT). The influence of SPECT reconstruction methodology on semiquantification and the clinical valueof I-123-IBZM SPECT were evaluated. Delineation of the striatal uptake and striatum/frontal cortex (ST/FC) ratios were improved by the use of compensation procedures for scatter and attenuation as well as the choice of an adequate filter. Satisfactory results were achieved usinga Metz prefilter with a comparatively high order number (i.e. high cut-off and low suppression of higher frequencies via roll-off). Regarding clincal diagnoses it was not possible to differentiate between advanced idiopathic Parkinson's disease (IP) and Parkinsonism of other aetiology (OP) on the basis of I-123-IBZM SPECT. But patients with IP andfavourable response to L-Dopa showed significantly higher ST/FC ratios than those with fluctuating response. In patients with dystonia ST/FC ratios were significantly higher compared to patients with IP or OP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:07:09