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Titolo:
SEROTONERGIC FUNCTION AND SELF-INJURIOUS-BEHAVIOR IN PERSONALITY-DISORDER PATIENTS
Autore:
NEW AS; TRESTMAN RL; MITROPOULOU V; BENISHAY DS; COCCARO E; SILVERMAN J; SIEVER LJ;
Indirizzi:
VET ADM MED CTR,PSYCHIAT SERV 116A,130 W KINGSBRIDGE RD BRONX NY 10468 MT SINAI MED CTR NEW YORK NY 10029 MED COLL PENN & HAHNEMANN UNIV PHILADELPHIA PA 19129
Titolo Testata:
Psychiatry research
fascicolo: 1, volume: 69, anno: 1997,
pagine: 17 - 26
SICI:
0165-1781(1997)69:1<17:SFASIP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BORDERLINE PERSONALITY; CEREBROSPINAL-FLUID; 5-HYDROXYINDOLEACETIC ACID; NEUROENDOCRINE RESPONSES; DEPRESSED-PATIENTS; HORMONE RESPONSES; FENFLURAMINE; PROLACTIN; CORTISOL; SUICIDE;
Keywords:
SEROTONIN; SUICIDE; GENDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A.S. New et al., "SEROTONERGIC FUNCTION AND SELF-INJURIOUS-BEHAVIOR IN PERSONALITY-DISORDER PATIENTS", Psychiatry research, 69(1), 1997, pp. 17-26

Abstract

Self-directed aggression, whether in the form of non-suicidal self-mutilation or suicidal behavior, is a prominent feature of personality disorders. We hypothesized that self-injurious behavior, like suicidal behavior, represents a form of self-directed aggression, and may, likesuicidal behavior and impulsive aggression, be associated with a decrease in central serotonin function in personality disorder patients. Ninety-seven patients with DSM-III personality disorder underwent D,L-fenfluramine challenge as an assessment of serotonergic activity. Patients with a history of self-mutilation or suicide had blunted prolactinand cortisol responses to D,L-fenfluramine compared to those with neither, and those with both had the most blunted responses to fenfluramine. These data raise the possibility that the central 5-HT abnormality, previously associated with suicidal behavior, may be associated withself-directed violence and not necessarily specifically with suicidalintent. (C) 1997 Elsevier Science Ireland Ltd.

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Documento generato il 25/01/20 alle ore 19:35:16