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Titolo:
CROSS-REACTIVITY OF ANTI-MYCOBACTERIUM GORDONAE ANTIBODIES WITH THE MAJOR MITOCHONDRIAL AUTOANTIGENS IN PRIMARY BILIARY-CIRRHOSIS
Autore:
VILAGUT L; VILA J; VINAS O; PARES A; GINES A; DEANTA MTJ; RODES J;
Indirizzi:
UNIV BARCELONA,HOSP CLIN & PROVINCIAL,LIVER UNIT,VILLARROEL 170 E-08036 BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROVINCIAL,LIVER UNIT E-08036 BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROVINCIAL,MICROBIOL LAB BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROVINCIAL,SERV IMMUNOL BARCELONA SPAIN
Titolo Testata:
Journal of hepatology
fascicolo: 4, volume: 21, anno: 1994,
pagine: 673 - 677
SICI:
0168-8278(1994)21:4<673:COAGAW>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE; PROTEIN;
Keywords:
ANTIMITOCHONDRIAL AUTOANTIBODIES; AUTOIMMUNITY; MOLECULAR MIMICRY; MYCOBACTERIAL COMPONENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
L. Vilagut et al., "CROSS-REACTIVITY OF ANTI-MYCOBACTERIUM GORDONAE ANTIBODIES WITH THE MAJOR MITOCHONDRIAL AUTOANTIGENS IN PRIMARY BILIARY-CIRRHOSIS", Journal of hepatology, 21(4), 1994, pp. 673-677

Abstract

Primary biliary cirrhosis is a chronic cholestatic liver disease associated with autoimmune disorders. Antimitochondrial autoantibodies andgranulomatous portal lesions are characteristic in primary biliary cirrhosis. Since granuloma may be induced by Mycobacteria, and there is evidence implicating Mycobacteria as infectious agents capable of initiating autoimmunity, a study was performed to determine the presence of antibodies against 10 atypical Mycobacteria in 19 patients with primary biliary cirrhosis, and in 35 controls (25 patients with other chronic liver diseases and 10 healthy subjects). All primary biliary cirrhosis sera and none of the controls reacted with the extract from Mycobacterium gordonae, showing identical recognition profiles with two polypeptides of 70-65 and 55 kDa. No other reaction was found in primary biliary cirrhosis patients and in controls with the extracts from the other nine atypical Mycobacteria tested. fluted immunoglobulins which reacted with the 70-65 and 55 kDa polypeptides from M. gordonae, boundto the mitochondrial antigens PDH-E2 and BCKDH-E2. Furthermore, when the extract from M. gordonae was tested with eluted immunoglobulins from recognized PDH-E2 and BCKDH-E2 by primary biliary cirrhosis patients, cross observed both 70-65 and 55 kDa polypeptides. These data indicate that antibodies to M. gordonae, found in all primary biliary cirrhosis patients, cross-react with the major mitochondrial targets of thedisease. We suggest that M. gordonae may play a potential pathogenic role in primary biliary cirrhosis. (C) Journal of Hepatology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 21:17:06