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Titolo:
GLUCOSE-TRANSPORTER PROTEINS IN BRAIN
Autore:
MAHER F; VANNUCCI SJ; SIMPSON IA;
Indirizzi:
BLDG 10,ROOM 5N102 BETHESDA MD 20892 NIDDKD BETHESDA MD 20892 PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT PEDIAT HERSHEY PA 17033
Titolo Testata:
The FASEB journal
fascicolo: 13, volume: 8, anno: 1994,
pagine: 1003 - 1011
SICI:
0892-6638(1994)8:13<1003:GPIB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; GENE-EXPRESSION; INSITU HYBRIDIZATION; PRIMARY CULTURES; XENOPUS OOCYTES; SMALL-INTESTINE; GROWTH-FACTOR; GLIAL-CELLS; BARRIER; GLUT3;
Keywords:
GLUCOSE TRANSPORT; CEREBRAL GLUCOSE UTILIZATION; NEURONS; GLIA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
F. Maher et al., "GLUCOSE-TRANSPORTER PROTEINS IN BRAIN", The FASEB journal, 8(13), 1994, pp. 1003-1011

Abstract

Glucose is the principal energy source for the mammalian brain. The presence of glucose transport proteins is essential to supply glucose to the neurons and glia within the brain. At least three glucose transporter isoforms have now been identified, and are thought to play a significant role, in the brain. This review describes our current understanding of cell-specific glucose transporter expression in brain, whichincludes GLUT1 (55-kDa form) present at a high concentration at the blood-brain barrier as well as in parenchymal cells (45-kDa form), mostlikely in astrocytes, GLUT3 expressed in neurons, and GLUT5 in microglia. We discuss some potential implications of this glucose transporter heterogeneity for cerebral metabolic activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:39:50