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Titolo:
SEROLOGICAL PANCREATIC TUMOR-MARKERS AND THE MUC1 APOMUCIN
Autore:
HO JJL; KIM YS;
Indirizzi:
VET ADM MED CTR,GI RES LAB 151M2,4150 CLEMENT ST SAN FRANCISCO CA 94121 UNIV CALIF SAN FRANCISCO,DEPT MED SAN FRANCISCO CA 00000
Titolo Testata:
Pancreas
fascicolo: 6, volume: 9, anno: 1994,
pagine: 674 - 691
SICI:
0885-3177(1994)9:6<674:SPTATM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHIC EPITHELIAL MUCIN; CANCER-ASSOCIATED ANTIGEN; CELL-SURFACE SIALOMUCIN; MURINE MONOCLONAL-ANTIBODIES; CARCINOMA-ASSOCIATED MUCIN; SIALYL-LEWIS-X; MAMMARY ADENOCARCINOMA CELLS; METASTATIC COLORECTAL-CANCER; HUMAN COLONIC MUCIN; CARCINOEMBRYONIC ANTIGEN;
Keywords:
PANCREATIC ADENOCARCINOMA; MUCINS; CA19-9; MUC1;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
230
Recensione:
Indirizzi per estratti:
Citazione:
J.J.L. Ho e Y.S. Kim, "SEROLOGICAL PANCREATIC TUMOR-MARKERS AND THE MUC1 APOMUCIN", Pancreas, 9(6), 1994, pp. 674-691

Abstract

Over 80% of adenocarcinomas of the pancreas originate from duct cells, which are the major source of mucins in the pancreas. Pathological conditions produce changes in the composition and structure of the oligosaccharides of colonic and pancreatic mucins, and it has been suggested that mucins may have a role in the detection of pancreatic cancer. Mucins are now the targets of a number of immunodiagnostic assays for cancer, and their possible use in therapy is being studied. This review describes the structure, biosynthesis, and release of mucins, as well as some of their therapeutic applications. The MUC1 type of mucin isemphasized because it is the main type present in bath normal and malignant pancreas and because it is associated with several of the serological pancreatic cancer carbohydrate markers, including CA19-9.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:37:10