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Titolo:
ASTROCYTES IMPLICATED IN THE ENERGIZING OF INTERMEDIATE MEMORY PROCESSES IN NEONATE CHICKS
Autore:
ODOWD BS; GIBBS ME; SEDMAN GL; NG KT;
Indirizzi:
LA TROBE UNIV BUNDOORA VIC 3083 AUSTRALIA LA TROBE UNIV BUNDOORA VIC 3083 AUSTRALIA
Titolo Testata:
Cognitive brain research
fascicolo: 2, volume: 2, anno: 1994,
pagine: 93 - 102
SICI:
0926-6410(1994)2:2<93:AIITEO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY CULTURES; ENERGY-METABOLISM; GLIAL-CELLS; ADRENERGIC AGONISTS; CELLULAR-LEVEL; BRAIN; FLUOROCITRATE; FLUOROACETATE; GLUTAMATE; GLYCOGEN;
Keywords:
MEMORY; CHICK; ASTROCYTE; ENERGY; METABOLISM; OXIDATIVE METABOLISM; GLYCOLYSIS; GLYCOGENOLYSIS; FLUOROCITRATE; FLUOROACETATE; IODOACETATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
B.S. Odowd et al., "ASTROCYTES IMPLICATED IN THE ENERGIZING OF INTERMEDIATE MEMORY PROCESSES IN NEONATE CHICKS", Cognitive brain research, 2(2), 1994, pp. 93-102

Abstract

Day-old chicks trained in a single trial passive avoidance task develop three sequentially dependent stages of discrimination memory. The second intermediate stage is made up of two phases: the initial A phasebeing susceptible to inhibition of oxidative metabolism in the tricarboxcylic acid (TCA) system with 2,4-dinitrophenol (DNP), and a second DNP-insensitive B phase. The studies reported in this paper found thatdoses of the metabolic toxins fluoroacetate (0.2 mM) and fluorocitrate (0.1 mM) previously reported to disrupt the astrocytic TCA cycle only, also disrupt the A (but not the B) phase of intermediate memory, suggesting an interaction between the astrocytic and neuronal oxidative systems may be required to meet the metabolic demands of this earlier phase. The B phase, on the other hand, was not expressed in the presence of the glycolytic inhibitor iodoacetate (1 mM), suggesting that glycolysis (known to be more efficient in astrocytes) and glycogenolysis (which may be exclusive to astrocytes) may support this second phase of intermediate memory. In this regard, the rise in forebrain noradrenaline levels previously reported to occur before the appearance of the B phase is particularly relevant. Given that noradrenaline has been shown to be capable of enhancing glycogenolysis in astrocyte-enriched cell cultures, it is conceivable that noradrenaline exerts an effect on memory by stimulating the glycolytic system in astrocytes, thereby providing energy or metabolites (e.g. pyruvate) needed to sustain the cellular processes operating during the B phase of intermediate memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:38:16