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Titolo:
STABILITY OF AMOXICILLIN AND POTASSIUM CLAVULANATE IN CO-AMOXICLAV ORAL SUSPENSION
Autore:
MEHTA AC; HARTDAVIES S; PAYNE J; LACEY RW;
Indirizzi:
GEN INFIRM,DEPT PHARM LEEDS LS1 3EX W YORKSHIRE ENGLAND GEN INFIRM,DEPT MICROBIOL LEEDS LS1 3EX W YORKSHIRE ENGLAND
Titolo Testata:
Journal of clinical pharmacy and therapeutics
fascicolo: 5, volume: 19, anno: 1994,
pagine: 313 - 315
SICI:
0269-4727(1994)19:5<313:SOAAPC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
4
Recensione:
Indirizzi per estratti:
Citazione:
A.C. Mehta et al., "STABILITY OF AMOXICILLIN AND POTASSIUM CLAVULANATE IN CO-AMOXICLAV ORAL SUSPENSION", Journal of clinical pharmacy and therapeutics, 19(5), 1994, pp. 313-315

Abstract

A study was carried out using high performance liquid chromatography (HPLC) to determine the chemical stability of amoxycillin and potassium clavulanate in 250/62 co-amoxyclav oral suspension (Augmentin), stored at room temperature (RT, 20-degrees-C) and 8-degrees-C over a period of 11 days. The suspension was judged to be acceptable if its components maintained at least 90% of their label concentrations. During thetest period, the amoxycillin component was found to be more stable than the clavulanate. Amoxycillin was stable for 7 days at both temperatures. Potassium clavulanate maintained at least 90% of its initial concentration for 7 days at 8-degrees-C but showed more than 40% degradation in the same time period at RT. For potassium clavulate the shelf-life, or time taken for the original concentration to drop to 90% of its value (t90) at RT was found to be 2 days.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:38:18