Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DEOXYRIBONUCLEOSIDE TRIPHOSPHATE LEVELS - A CRITICAL FACTOR IN THE MAINTENANCE OF GENETIC STABILITY
Autore:
KUNZ BA; KOHALMI SE; KUNKEL TA; MATHEWS CK; MCINTOSH EM; REIDY JA;
Indirizzi:
UNIV MANITOBA,DEPT MICROBIOL WINNIPEG R3T 2N2 MB CANADA NATL RES COUNCIL CANADA,INST PLANT BIOTECHNOL SASKATOON S7N 0W9 SK CANADA NIEHS,MOLEC GENET LAB RES TRIANGLE PK NC 27709 OREGON STATE UNIV,DEPT BIOCHEM & BIOPHYS CORVALLIS OR 97331 YORK UNIV,DEPT BIOL N YORK M3J 1P3 ON CANADA CTR DIS CONTROL & PREVENT,NATL CTR ENVIRONM HLTH,MOLEC BIOL BRANCH ATLANTA GA 30341
Titolo Testata:
Mutation research. Reviews in genetic toxicology
fascicolo: 1, volume: 318, anno: 1994,
pagine: 1 - 64
SICI:
0165-1110(1994)318:1<1:DTL-AC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAMSTER OVARY CELLS; SISTER-CHROMATID EXCHANGES; COMMON FRAGILE SITES; DNA PRECURSOR POOL; MOUSE FM3A CELLS; THYMINE NUCLEOTIDE DEPLETION; RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE; IMMUNODEFICIENCY-VIRUS COMPOUND; CANCER CHEMOTHERAPEUTIC-AGENTS; YEAST SACCHAROMYCES-CEREVISIAE;
Keywords:
DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; GENETIC STABILITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
513
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Kunz et al., "DEOXYRIBONUCLEOSIDE TRIPHOSPHATE LEVELS - A CRITICAL FACTOR IN THE MAINTENANCE OF GENETIC STABILITY", Mutation research. Reviews in genetic toxicology, 318(1), 1994, pp. 1-64

Abstract

DNA precursor pool imbalances can elicit a variety of genetic effectsand modulate the genotoxicity of certain DNA-damaging agents. These and other observations indicate that the control of DNA precursor concentrations is essential for the maintenance of genetic stability, and suggest that factors which offset this control may contribute to environmental mutagenesis and carcinogenesis. In this article, we review thebiochemical and genetic mechanisms responsible for regulating the production and relative amounts of intracellular DNA precursors, describethe many outcomes of perturbations in DNA precursor levels, and discuss implications of such imbalances for sensitivity to DNA-damaging agents, population monitoring, and human diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 06:01:16