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Titolo:
PHYSICOCHEMICAL AND PHYSIOLOGICAL-MECHANISMS FOR THE EFFECTS OF FOOD ON DRUG ABSORPTION - THE ROLE OF LIPIDS AND PH
Autore:
CHARMAN WN; PORTER CJH; MITHANI S; DRESSMAN JB;
Indirizzi:
MONASH UNIV,VICTORIAN COLL PHARM,DEPT PHARMACEUT,PARKVILLE CAMPUS,381ROYAL PARADE PARKVILLE VIC 3052 AUSTRALIA UNIV MICHIGAN,COLL PHARM ANN ARBOR MI 48109 UNIV FRANKFURT,INST PHARMAZEUT TECHNOL D-60439 FRANKFURT GERMANY
Titolo Testata:
Journal of pharmaceutical sciences
fascicolo: 3, volume: 86, anno: 1997,
pagine: 269 - 282
SICI:
0022-3549(1997)86:3<269:PAPFTE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; INTESTINAL LYMPHATIC TRANSPORT; DUODENAL-ULCER PATIENTS; POORLY ABSORBED DRUGS; PHYSICAL-CHEMICAL BEHAVIOR; NON-DISINTEGRATING TABLETS; MEDIUM-CHAIN TRIGLYCERIDES; ALPHA-TOCOPHEROL ACETATE; MIXED MICELLAR SOLUTIONS; MIGRATING MOTOR COMPLEX;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
263
Recensione:
Indirizzi per estratti:
Citazione:
W.N. Charman et al., "PHYSICOCHEMICAL AND PHYSIOLOGICAL-MECHANISMS FOR THE EFFECTS OF FOOD ON DRUG ABSORPTION - THE ROLE OF LIPIDS AND PH", Journal of pharmaceutical sciences, 86(3), 1997, pp. 269-282

Abstract

Drugs are absorbed after oral administration as a consequence of a complex array of interactions between the drug, its formulation, and thegastrointestinal (GI) tract. The presence of food within the Gi tractimpacts significantly on transit profiles, pH, and its solubilizationcapacity. Consequently, food would be expected to affect the absorption of co-administered drugs when their physicochemical properties are sensitive to these changes. The physicochemical basis by which ingested food/lipids induce changes in the GI tract and influence drug absorption are reviewed. The process of lipid digestion is briefly reviewed and considered in the context of the absorption of poorly water-soluble drugs. The effect of food on GI pH is reviewed in terms of location (stomach, upper and lower small intestine) and the temporal relationship between pH and drug absorption. Case studies are presented in whichpostprandial changes in bioavailability are rationalized in terms of the sensitivity of the physicochemical properties of the administered drug to the altered GI environment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:34:58