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Titolo:
GASTRIN RECEPTOR GENES ARE EXPRESSED IN GASTRIC PARIETAL AND ENTEROCHROMAFFIN-LIKE CELLS OF MASTOMYS-NATALENSIS
Autore:
ASAHARA M; KINOSHITA Y; NAKATA H; MATSUSHIMA Y; NARIBAYASHI Y; NAKAMURA A; MATSUI T; CHIHARA K; YAMAMOTO J; ICHIKAWA A; CHIBA T;
Indirizzi:
KOBE UNIV,SCH MED,DEPT INTERNAL MED,DIV GERONTOL,CHUO KU,KUSUNOKI CHO7-5-2 KOBE 650 JAPAN KOBE UNIV,SCH MED,DEPT INTERNAL MED,DIV GERONTOL,CHUO KU KOBE 650 JAPAN KOBE UNIV,SCH MED,DEPT INTERNAL MED,DIV 3 KOBE 650 JAPAN KYOTO UNIV,FAC PHARMACEUT SCI,DEPT PHYSIOL CHEM KYOTO 606 JAPAN
Titolo Testata:
Digestive diseases and sciences
fascicolo: 10, volume: 39, anno: 1994,
pagine: 2149 - 2156
SICI:
0163-2116(1994)39:10<2149:GRGAEI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOID-TUMOR MEMBRANE; PERFUSED RAT STOMACH; FUNDIC D-CELLS; ACID-SECRETION; HISTAMINE-RELEASE; PERNICIOUS-ANEMIA; MUCOSAL CELLS; HYPERPLASIA; CLONING; CHOLECYSTOKININ;
Keywords:
MASTOMYS NATALENSIS; GASTRIN RECEPTOR; HISTIDINE DECARBOXYLASE; H+; K+-ATPASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M. Asahara et al., "GASTRIN RECEPTOR GENES ARE EXPRESSED IN GASTRIC PARIETAL AND ENTEROCHROMAFFIN-LIKE CELLS OF MASTOMYS-NATALENSIS", Digestive diseases and sciences, 39(10), 1994, pp. 2149-2156

Abstract

Although gastric enterochromaffin-like (ECL) carcinoid tumors are known to develop in patients with long-standing hypergastrinemia, the expression of the gastrin receptor gene in ECL cells has not yet been demonstrated. Therefore this study was designed to examine gastrin receptor gene expression in ECL cells. Mastomys gastric mucosal cells isolated by enzyme dispersion were separated into 10 fractions (F1-IO) by centrifugal elutriation. Each fraction was examined histologically to determine whether they contained ECL and/or parietal cells and Northern blot analysis was used to confirm the presence of histidine decarboxylase and H+, K+-ATPase gene expression. ECL cells were found only in fractions 1 and 2, whereas parietal cells were detected in fractions 6-10. Gastrin receptor gene expression was demonstrated in both parietal cell-rich and ECL cell-rich fractions. In addition, the gastrin receptor cDNA sequences obtained from the two of the fractions (F1 and 8) were identical. These results suggest that gastrin receptor genes are expressed in ECL cells as well as in parietal cells and that these receptors are identical.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:13:33