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Titolo:
MODULATION OF CYTOKINE EXPRESSION IN MOUSE DENDRITIC CELL CLONES
Autore:
GRANUCCI F; GIROLOMONI G; LUTZ MB; FOTI M; MARCONI G; GNOCCHI P; NOLLI L; RICCIARDICASTAGNOLI P;
Indirizzi:
UNIV MILAN,CNR,CTR CYTOPHARMACOL,DEPT PHARMACOL,VIA VANVITELLI 32 I-20129 MILAN ITALY UNIV MILAN,CNR,CTR CYTOPHARMACOL,DEPT PHARMACOL I-20129 MILAN ITALY UNIV MODENA,DEPT DERMATOL I-41100 MODENA ITALY PHARM FARMITALIA CARLO ERBA,BUSINESS AREA ONCOL IMMUNOL NERVIANO ITALY LEPETIT RES CTR,MMDRI GERENZANO ITALY
Titolo Testata:
European Journal of Immunology
fascicolo: 10, volume: 24, anno: 1994,
pagine: 2522 - 2526
SICI:
0014-2980(1994)24:10<2522:MOCEIM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; TRANSFORMING GROWTH-FACTOR; STIMULATORY FACTOR INTERLEUKIN-12; ANTIGEN-PRESENTING FUNCTION; CD4+ T-CELLS; LANGERHANS CELLS; IMMUNE-RESPONSES; EPIDERMAL-CELLS; FACTOR-ALPHA; FACTOR-BETA;
Keywords:
ANTIGEN-PRESENTING CELLS; COSTIMULATORY SIGNALS; ACTIVATING SIGNALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
F. Granucci et al., "MODULATION OF CYTOKINE EXPRESSION IN MOUSE DENDRITIC CELL CLONES", European Journal of Immunology, 24(10), 1994, pp. 2522-2526

Abstract

Dendritic cells (DC) play an essential role in the induction of primary immune responses; however, very little information is available on cytokine production by DC. Here we determined the cytokine gene expression profile of two immortalized DC clones, CB1 and D2SC/1, bath generated from mouse spleen but differing in their activation requirements. Among the cytokines tested, only transforming growth factor-beta 1 was transcribed constitutively, but its production was detected only in D2SC/1 cells after treatment with granulocyte/macrophage colony-stimulating factor (GM-CSF). GM-CSF also promoted transcription and synthesis of interleukin (IL)-1 beta in CB1 cells that need pretreatment with GM-CSF to present major histocompatibility complex class II-restrictedantigens efficiently in vitro. Lipopolysaccharide (LPS) up-regulated gene expression and induced release of tumor necrosis factor-alpha in both DC clones. In addition, LPS induced transcription of IL-1 alpha and both gene expression and synthesis of IL-1 beta in D2SC/1 cells. Interferon-gamma was ineffective in inducing cytokine gene expression, although it augmented the antigen-presentation capacity of DC. IL-4, IL-10 and IL-12 mRNA were not induced by any of the tested stimuli. The results suggest that DC have a limited cytokine gene expression pattern compared to macrophages and are heterogenous in some functional properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:12:50