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Titolo:
ADHESION MOLECULES FROM THE LFA-1 ICAM-1,3 AND VLA-4/VCAM-1 PATHWAYS ON T-LYMPHOCYTES AND VASCULAR ENDOTHELIUM IN GRAVES AND HASHIMOTOS THYROID-GLANDS/
Autore:
MARAZUELA M; POSTIGO AA; ACEVEDO A; DIAZGONZALEZ F; SANCHEZMADRID F; DELANDAZURI MO;
Indirizzi:
UNIV AUTONOMA MADRID,HOSP PRINCESA,SERV ENDOCRINOL,DIEGO LEON 62 E-28006 MADRID SPAIN UNIV AUTONOMA MADRID,HOSP PRINCESA,SERV IMMUNOL MADRID SPAIN UNIV AUTONOMA MADRID,HOSP PRINCESA,PATHOL SERV MADRID SPAIN UNIV AUTONOMA MADRID,HOSP PRINCESA,RHEUMATOL SERV MADRID SPAIN
Titolo Testata:
European Journal of Immunology
fascicolo: 10, volume: 24, anno: 1994,
pagine: 2483 - 2490
SICI:
0014-2980(1994)24:10<2483:AMFTLI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION; MONOCLONAL-ANTIBODIES; RHEUMATOID-ARTHRITIS; ACTIVATION ANTIGEN; COUNTER-RECEPTOR; INTERFERON-GAMMA; EPITHELIAL-CELLS; GERMINAL-CENTERS; INTEGRIN VLA-4; HUMAN TISSUES;
Keywords:
CELL ADHESION MOLECULES; AUTOIMMUNE THYROID DISORDERS; GRAVES DISEASE IMMUNOLOGY; VASCULAR IMMUNOLOGY; T LYMPHOCYTE IMMUNOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
M. Marazuela et al., "ADHESION MOLECULES FROM THE LFA-1 ICAM-1,3 AND VLA-4/VCAM-1 PATHWAYS ON T-LYMPHOCYTES AND VASCULAR ENDOTHELIUM IN GRAVES AND HASHIMOTOS THYROID-GLANDS/", European Journal of Immunology, 24(10), 1994, pp. 2483-2490

Abstract

Lymphocytic infiltration of the thyroid gland in autoimmune thyroid disorders requires, as a first step, their attachment to endothelial cells (EC) and, subsequently, their interaction with thyrocytes and extracellular matrix proteins. A number of different ligand molecules havebeen identified to mediate the interaction between EC and leukocyte subpopulations. In this study, we examined by flow cytometry and immunohistochemical techniques, the expression of integrin receptors and their counter-receptors by infiltrating lymphocytes and vascular endothelium in thyroid glands from patients with Graves' disease (GD) and Hashimoto's thyroiditis (HT). A high proportion of GD intrathyroidal T lymphocytes expressed the CD69 and gp95/85 (Ea2) activation antigens as well as an increased number of LFA-alpha(L), VLA-alpha 1, -alpha 4, -alpha 5, and -beta 1 integrin receptors, as compared with peripheral blood T lymphocytes from the same patients. The expression of intercellular adhesion molecule (ICAM)-1 was increased in EC from GD and HT thyroids. In addition, an up-regulated de novo expression of vascular cell adhesion molecule (VCAM)-1 was found in EC in GD and HT thyroids, withno reactivity in control thyroids. Dendritic cells in thyroid lymphoid follicles were also positive for ICAM-1 and VCAM-1. In addition, most of intrathyroidal mononuclear cells expressed the ICAM-3 adhesion molecule. This enhanced expression of ICAM-1 and VCAM-1 by thyroid EC inGD and HT may reflect their ability to regulate leukocyte traffickingand activation by means of the expression of specific ligand molecules. Our data suggest that both the LFA-1/ICAM-1, ICAM-3 and VLA-4/VCAM-1 pathways could play a relevant role in localizing and perpetuating the autoimmune response in the thyroid gland in autoimmune thyroid disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:56:46