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Titolo:
CD4(-) T-CELLS ARE THE EFFECTOR-CELLS IN DISEASE PATHOGENESIS IN THE SCURFY (SF) MOUSE()CD8()
Autore:
BLAIR PJ; BULTMAN SJ; HAAS JC; ROUSE BT; WILKINSON JE; GODFREY VL;
Indirizzi:
OAK RIDGE NATL LAB,DIV BIOL,POB 2009 OAK RIDGE TN 37831 OAK RIDGE NATL LAB,DIV BIOL OAK RIDGE TN 37831 USN,MED RES INST,IMMUNE CELL BIOL PROGRAM BETHESDA MD 20889 UNIV TENNESSEE,DEPT MICROBIOL KNOXVILLE TN 37901 UNIV TENNESSEE,COLL VET MED KNOXVILLE TN 37901
Titolo Testata:
The Journal of immunology
fascicolo: 8, volume: 153, anno: 1994,
pagine: 3764 - 3774
SICI:
0022-1767(1994)153:8<3764:CTATEI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; LYMPHORETICULAR DISEASE; MONOCLONAL-ANTIBODIES; LYMPHOKINE ACTIVITIES; POSITIVE SELECTION; LYMPHOCYTES-T; B-CELLS; ANTIGEN; MICE; HELPER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Blair et al., "CD4(-) T-CELLS ARE THE EFFECTOR-CELLS IN DISEASE PATHOGENESIS IN THE SCURFY (SF) MOUSE()CD8()", The Journal of immunology, 153(8), 1994, pp. 3764-3774

Abstract

hemizygous for the X-linked mutation, scurfy (sf), exhibit a fatal lymphoreticular disease that is mediated by T lymphocytes. To evaluate the respective roles of CD4 or CD8 single positive T cells in scurfy disease, neonates were treated with mAbs directed against the CD4 or CD8molecules. Whereas mice treated with an anti-CD8 Ab developed lesionsand succumbed to disease at the same time (17 days) as their untreated scurfy littermates, mice treated with an anti-CD4 Ab lived up to 11 wk before developing scurfy disease. To insure a more complete elimination of the T cell subsets, the scurfy mutation was bred onto beta(2)-microglobulin (beta(2)m)-deficient (CD8-less) and CD4-deficient transgenic mouse lines. Whereas there was little moderation of disease in beta(2)m-deficient scurfy mice, CD4-deficient scurfy mice had markedly decreased scurfy lesions and a prolonged life span, similar to that of anti-CD4-treated sf/Y mice. Additionally, scurfy disease was transplanted into H-2-compatible nude mice through the adoptive transfer of CD4(+)CD8(-) T cells, but not CD4(-)CD8(+) T cells. Flow-cytometric analysis revealed that sf/Y mice have an increased percentage of activated CD4(+) T cells in their lymph nodes. In addition, there is an increasein the in vitro production of cytokines in the cultured splenocytes of CD8-less, but not CD4-less, scurfy mice. These data suggest that CD4(+) T cells are critical mediators of disease in the scurfy mouse.

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Documento generato il 29/11/20 alle ore 06:54:43