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Titolo:
ACTIVITY-DEPENDENT AND HORMONAL-REGULATION OF NEUROTROPHIN MESSENGER-RNA LEVELS IN THE BRAIN - IMPLICATIONS FOR NEURONAL PLASTICITY
Autore:
LINDHOLM D; CASTREN E; BERZAGHI M; BLOCHL A; THOENEN H;
Indirizzi:
MAX PLANCK INST PSYCHIAT,DEPT NEUROCHEM D-82152 MARTINSRIED GERMANY
Titolo Testata:
Journal of neurobiology
fascicolo: 11, volume: 25, anno: 1994,
pagine: 1362 - 1372
SICI:
0022-3034(1994)25:11<1362:AAHONM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; FACTOR MESSENGER-RNA; ADULT-RAT BRAIN; FACTOR NGF SYNTHESIS; LONG-TERM POTENTIATION; FACTOR GENE-EXPRESSION; HIPPOCAMPAL-NEURONS; KAINIC ACID; DIFFERENTIAL REGULATION; LIMBIC SEIZURES;
Keywords:
NEUROTROPHINS; ACTIVITY-DEPENDENT REGULATION OF SYNTHESIS; NEURONAL PLASTICITY; HORMONAL REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
78
Recensione:
Indirizzi per estratti:
Citazione:
D. Lindholm et al., "ACTIVITY-DEPENDENT AND HORMONAL-REGULATION OF NEUROTROPHIN MESSENGER-RNA LEVELS IN THE BRAIN - IMPLICATIONS FOR NEURONAL PLASTICITY", Journal of neurobiology, 25(11), 1994, pp. 1362-1372

Abstract

The neurotrophins exhibit neurotrophic effects on specific, partiallyoverlapping populations of neurons both in the peripheral and the central nervous system (CPU'S). In the periphery, they are synthesized bya variety of nonneuronal cells, and their synthesis seems to be independent of the neuronal input. In contrast, in the CNS all neurotrophins are expressed under physiological conditions primarily by neurons. The production of NGF and BDNF is controlled by neuronal activity: up-regulation by glutamate and acetylcholine, down-regulation by gamma-aminobutyric acid. In contrast, NT-3 regulation is independent of neuronal activity, but it is up-regulated by thyroid hormones and BDNF. The latter observation suggests that NT-3 might be controlled indirectly byneuronal activity via BDNF. In peripheral nonneuronal tissues, glucocorticoid hormones down-regulate NGF mRNA levels both in vitro and in vivo. In contrast, in the CNS, neuronal production of NGF is enhanced by glucocorticoids. The rapid regulation of NGF and BDNF by subtle physiological stimuli together with the recent demonstration that the neurotrophins release neurotransmitters such as acetylcholine opens up interesting perspectives for the function of neurotrophins as mediators of neuronal plasticity. (C) 1994 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:14:03