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Titolo:
GLUTAMATE, LEARNING AND DEMENTIA-SELECTION OF EVIDENCE
Autore:
DANYSZ W; ARCHER T;
Indirizzi:
MERZ & CO,DEPT PHARMACOL,POB 111353 D-60048 FRANKFURT GERMANY GOTHENBURG UNIV,DEPT PSYCHOL GOTHENBURG SWEDEN
Titolo Testata:
Amino acids
fascicolo: 2, volume: 7, anno: 1994,
pagine: 147 - 163
SICI:
0939-4451(1994)7:2<147:GLADOE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID RECEPTORS; D-ASPARTATE RECEPTOR; LONG-TERM POTENTIATION; RADIAL ARM MAZE; RAT HIPPOCAMPAL SLICES; NMDA ANTAGONISTS CPP; AGE-RELATED-CHANGES; ALZHEIMERS-DISEASE; D-CYCLOSERINE; SYNAPTIC PLASTICITY;
Keywords:
AMINO ACIDS LEARNING; DEMENTIA; GLUTAMATE; NMDA ANTAGONISTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
135
Recensione:
Indirizzi per estratti:
Citazione:
W. Danysz e T. Archer, "GLUTAMATE, LEARNING AND DEMENTIA-SELECTION OF EVIDENCE", Amino acids, 7(2), 1994, pp. 147-163

Abstract

Initial suggestions on the involvement of glutamate in memory came from electrophysiological studies on LTP that is blocked by NMDA-antagonists. Then Morris and colleagues (1986) provided the first evidence that icv infusion of the competitive NMDA antagonist 2-amino-5-phosphonovaleric acid (APV) to rats, inhibits both LTP in vivo and spatial learning in a Morris water maze. This was followed by a great amount of evidence confirming the initial finding in various learning tasks. The present paper is devoted to critical review of the literature focusing on the following problems: which glutamate receptors are involved ?, in which tests NMDA antagonists inhibit learning ?; which types of memory are affected ?; which brain structures are involved ? do NMDA receptor antagonists invariably impair learning ?; is the effect of NMDA receptors antagonists on learning specific ?; does the stimulation of NMDA receptors result in cognitive enhancement ?.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 16:04:17