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Titolo:
DIFFERENTIAL-EFFECTS OF ACETYLCHOLINE ON NEURONAL-ACTIVITY AND INTERACTIONS IN THE AUDITORY-CORTEX OF THE GUINEA-PIG
Autore:
SHULZ DE; COHEN S; HAIDARLIU S; AHISSAR E;
Indirizzi:
INST ALFRED FESSARD,CNRS,EQUIPE COGNISCI,1 AVE TERRASSE F-91190 GIF SUR YVETTE FRANCE WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL
Titolo Testata:
European journal of neuroscience
fascicolo: 2, volume: 9, anno: 1997,
pagine: 396 - 409
SICI:
0953-816X(1997)9:2<396:DOAONA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAT VISUAL-CORTEX; CEREBRAL-CORTEX; CROSS-CORRELATION; BASAL FOREBRAIN; NUCLEUS BASALIS; STRIATE CORTEX; CHOLINERGIC INNERVATION; SOMATOSENSORY NEURONS; LAMINAR DISTRIBUTION; MUSCARINIC RECEPTOR;
Keywords:
ACETYLCHOLINESTERASE; AUTOCORRELATION; CARBACHOL; CROSS-CORRELATION; FUNCTIONAL CONNECTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Shulz et al., "DIFFERENTIAL-EFFECTS OF ACETYLCHOLINE ON NEURONAL-ACTIVITY AND INTERACTIONS IN THE AUDITORY-CORTEX OF THE GUINEA-PIG", European journal of neuroscience, 9(2), 1997, pp. 396-409

Abstract

During normal brain operations, cortical neurons are subjected to continuous cholinergic modulations. In vitro studies have indicated that,in addition to affecting general cellular excitability, acetylcholinealso modulates synaptic transmission. Whether these cholinergic mechanisms lead to a modulation of functional connectivity in vivo is not yet known. Herein, the effects were studied of an iontophoretic application of acetylcholine and of the muscarinic agonist, carbachol, on theongoing activity and co-activity of neurons simultaneously recorded in the auditory cortex of the anaesthetized guinea-pig. Iontophoresis of cholinergic agonists mainly affected the spontaneous firing rates ofauditory neurons, affected autocorrelations less (in most cases theircentral peak areas were reduced), and rarely affected cross-correlations. These findings are consistent with cholinergic agonists primarilyaffecting the excitability of cortical neurons rather than the strength of cortical connections. However, when changes of cross-correlations occurred, they were usually not correlated with concomitant changes in average firing rates nor with changes in autocorrelations, which suggests a secondary cholinergic effect on specific cortico-cortical or thalamo-cortical connections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:49:51