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Titolo:
TARGETED EXPRESSION OF THE SIGNALING MOLECULE DECAPENTAPLEGIC INDUCESPATTERN DUPLICATIONS AND GROWTH ALTERATIONS IN DROSOPHILA WINGS
Autore:
CAPDEVILA J; GUERRERO I;
Indirizzi:
UNIV AUTONOMA MADRID,CSIC,CTR BIOL MOLEC SEVERO OCHOA,CANTO BLANCO E-28049 MADRID SPAIN UNIV AUTONOMA MADRID,CSIC,CTR BIOL MOLEC SEVERO OCHOA E-28049 MADRID SPAIN
Titolo Testata:
EMBO journal
fascicolo: 19, volume: 13, anno: 1994,
pagine: 4459 - 4468
SICI:
0261-4189(1994)13:19<4459:TEOTSM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECONDARY EMBRYONIC FIELDS; CELL-CELL COMMUNICATION; POLARITY GENE COSTAL-2; TGF-BETA FAMILY; SEGMENT-POLARITY; IMAGINAL DISKS; WINGLESS PROTEIN; HEDGEHOG; ELEMENTS; SPECIFICATION;
Keywords:
DECAPENTAPLEGIC; HEDGEHOG; IMAGINAL DISC DEVELOPMENT; SEGMENT POLARITY GENES; TRANSFORMING GROWTH FACTOR-BETA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
J. Capdevila e I. Guerrero, "TARGETED EXPRESSION OF THE SIGNALING MOLECULE DECAPENTAPLEGIC INDUCESPATTERN DUPLICATIONS AND GROWTH ALTERATIONS IN DROSOPHILA WINGS", EMBO journal, 13(19), 1994, pp. 4459-4468

Abstract

In the wing imaginal disc, the decapentaplegic (dpp) gene is expressed in a stripe of anterior cells near the anterior-posterior compartment boundary, and it is required solely in these cells for the entire disc to develop. In some viable segment polarity mutants, alterations indpp expression have been demonstrated that correlate with changes in wing morphology. To test the hypothesis that the abnormal patterns of dpp expression are responsible directly for the mutant phenotypes, we have expressed dpp in ectopic places in wing imaginal discs, and we have found that dpp is able to cause overgrowth and pattern duplicationsin both anterior and posterior compartments of the wing disc. The alterations of the anterior compartment are strikingly similar to those observed in some viable segment polarity mutants. Thus, ectopic dpp alone can account for the phenotype of these mutants. We also show that ectopic expression of the segment polarity gene hedgehog (hh) gives similar morphological changes and activates dpp expression in the anterior compartment. This strongly suggests that the organizing activity of hh is mediated by dpp. We propose that the expression of dpp near the anterior-posterior compartment boundary is directed by the interactionbetween patched and hit, and that dpp itself could act as a general organizer of the patterning in the wing imaginal disc.

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Documento generato il 27/11/20 alle ore 22:04:14