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Titolo:
EVIDENCE FOR A MITOTIC CLOCK IN HUMAN HEMATOPOIETIC STEM-CELLS - LOSSOF TELOMERIC DNA WITH AGE
Autore:
VAZIRI H; DRAGOWSKA W; ALLSOPP RC; THOMAS TE; HARLEY CB; LANSDORP PM;
Indirizzi:
BRITISH COLUMBIA CANC AGCY,TERRY FOX LAB HEMATOL ONCOL,601 W 10TH AVEVANCOUVER V5Z 1L3 BC CANADA BRITISH COLUMBIA CANC AGCY,TERRY FOX LAB HEMATOL ONCOL VANCOUVER V5Z 1L3 BC CANADA UNIV BRITISH COLUMBIA,DEPT MED VANCOUVER BC CANADA GERON CORP MENLO PK CA 94025
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 21, volume: 91, anno: 1994,
pagine: 9857 - 9860
SICI:
0027-8424(1994)91:21<9857:EFAMCI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT BONE-MARROW; PROGENITOR CELLS; HUMAN FIBROBLASTS; CORD BLOOD; TRANSPLANTATION; EXPANSION; IDENTIFICATION; REPEATS; NUMBERS; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
H. Vaziri et al., "EVIDENCE FOR A MITOTIC CLOCK IN HUMAN HEMATOPOIETIC STEM-CELLS - LOSSOF TELOMERIC DNA WITH AGE", Proceedings of the National Academy of Sciences of the United Statesof America, 91(21), 1994, pp. 9857-9860

Abstract

The proliferative life-span of the stem cells that sustain hematopoiesis throughout life is not known. It has been proposed that the sequential loss of telomeric DNA from the ends of human chromosomes with each somatic cell division eventually reaches a critical point that triggers cellular senescence. We now show that candidate human stem cells with a CD34(+)CD38(lo) phenotype that were purified from adult bone marrow have shorter telomeres than cells from fetal liver or umbilical cord blood. We also found that cells produced in cytokine-supplemented cultures of purified precursor cells show a proliferation-associated loss of telomeric DNA. These findings strongly suggest that the proliferative potential of most, if not all, hematopoietic stem cells is limited and decreases with age, a concept that has widespread implications for models of normal and abnormal hematopoiesis as well as gene therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 10:59:49