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Titolo:
VASOPRESSIN MESSENGER-RNA CHANGES DURING KINDLING - THE EFFECTS OF KINDLING SITE AND STAGE
Autore:
GREENWOOD RS; ABDOU A; MEEKER RB; HAYWARD JN;
Indirizzi:
UNIV N CAROLINA,SCH MED,DEPT NEUROL,CB-7025,751 BURNETT WOMACK CHAPELHILL NC 27599 UNIV N CAROLINA,SCH MED,DEPT PEDIAT CHAPEL HILL NC 27599 UNIV N CAROLINA,SCH MED,NEUROBIOL CURRICULUM CHAPEL HILL NC 27599
Titolo Testata:
Molecular brain research
fascicolo: 1-2, volume: 26, anno: 1994,
pagine: 286 - 292
SICI:
0169-328X(1994)26:1-2<286:VMCDK->2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPRODUCTIVE ENDOCRINE DISORDERS; MESSENGER-RNA; SERUM PROLACTIN; INSITU HYBRIDIZATION; EPILEPTIC SEIZURES; RATS; SOMATOSTATIN; STIMULATION; EXPRESSION; CORTISOL;
Keywords:
KINDLING; SEIZURE; VASOPRESSIN; NEUROENDOCRINE; IN SITU HYBRIDIZATION; HYPOTHALAMUS; SUPRAOPTIC NUCLEUS; HIPPOCAMPUS; OLFACTORY BULB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Greenwood et al., "VASOPRESSIN MESSENGER-RNA CHANGES DURING KINDLING - THE EFFECTS OF KINDLING SITE AND STAGE", Molecular brain research, 26(1-2), 1994, pp. 286-292

Abstract

Because of the many anatomical and functional links to the limbic system, the neuroendocrine system is often affected by limbic disturbances. Limbic seizures in humans and animals alter neuroendocrine functionand hormone levels. We have shown that in an animal model for partialseizures, the amygdala kindred rat, plasma vasopressin levels are elevated and a sustained increase in vasopressin (VP) mRNA follows stage 5 kindled seizures. In the present experiments we sought to determine when during the course of amygdala kindling the VP mRNA increase occurs and whether specific anatomical pathways mediate this increase. Animals kindled to early seizure stages (stages 1, 2 or 3) had no consistent increase in VP mRNA in the supraoptic nucleus (SON) while animals kindled to generalized seizures, stages 4 or 5, invariably had increased VP mRNA relative to controls. Electrical kindling to stage 5 seizures from two other brain sites, the dorsal hippocampus and the anterior olfactory nucleus, consistently resulted in a significant increase in VP mRNA one week after completing kindling. In air experiments the increase in VP mRNA in the SON showed no differences related to the side or proximity of the electrodes used for kindling. Measures of water balance did not change following kindling. These results indicate that kindred seizure generalization is a prerequisite for the long-term increase in VP mRNA. Furthermore, the VP mRNA increase appears to involve polysynaptic pathways accessible from different limbic kindling sites. These studies support the hypothesis that changes in mRNA regulation may contribute to the neuroendocrine pathophysiology accompanying limbic seizures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 19:23:07