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Titolo:
TEMPORAL TRENDS IN THE INCIDENCE OF HTV-1-RELATED NEUROLOGIC DISEASES- MULTICENTER AIDS COHORT STUDY, 1985-1992
Autore:
BACELLAR H; MUNOZ A; MILLER EN; COHEN BA; BESLEY D; SELNES OA; BECKER JT; MCARTHUR JC;
Indirizzi:
JOHNS HOPKINS UNIV,600 N WOLFE ST,MEYER 6-109 BALTIMORE MD 21287 JOHNS HOPKINS UNIV BALTIMORE MD 21287 UNIV CALIF LOS ANGELES LOS ANGELES CA 00000 NORTHWESTERN UNIV,SCH MED CHICAGO IL 00000 UNIV PITTSBURGH PITTSBURGH PA 00000
Titolo Testata:
Neurology
fascicolo: 10, volume: 44, anno: 1994,
pagine: 1892 - 1900
SICI:
0028-3878(1994)44:10<1892:TTITIO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; PNEUMOCYSTIS-CARINII PNEUMONIA; NON-HODGKIN LYMPHOMA; DEMENTIA COMPLEX; VIRUS-INFECTION; TRIMETHOPRIM-SULFAMETHOXAZOLE; PERIPHERAL NEUROPATHY; CONTROLLED TRIAL; NATURAL-HISTORY; UNITED-STATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
H. Bacellar et al., "TEMPORAL TRENDS IN THE INCIDENCE OF HTV-1-RELATED NEUROLOGIC DISEASES- MULTICENTER AIDS COHORT STUDY, 1985-1992", Neurology, 44(10), 1994, pp. 1892-1900

Abstract

Objective: To describe temporal trends in the incidence of human immunodeficiency virus (HIV)-related neurologic diseases in the Multicenter AIDS Cohort Study from 1985 to 1992. Methods: The incidence rates ofsix neurologic disorders were examined: toxoplasmosis, cryptococcal meningitis, primary CNS lymphoma, progressive multifocal leukoencephalopathy, HIV dementia, and sensory neuropathy. Poisson modeling was usedto test linear trends over time and the effects of progressive immunosuppression, antimicrobial prophylaxis, and antiretroviral drug therapy. Results: There was an upward temporal trend in all incidence rates,except for HN dementia. Progressive immunosuppression in the cohort explained all calendar trends except for sensory neuropathy, where an increasing temporal trend remained even after adjusting for CD4(+) cellcount, and for HIV dementia where a slight decline was noted, although the effects were not statistically significant. We noted a protective trend of antimicrobial prophylaxis on toxoplasmosis and cryptococcalmeningitis, but, in contrast, use of antiretroviral agents was not protective against HIV dementia. Men receiving didanosine, zalcitabine, or stavudine were more likely to develop sensory neuropathy. Conclusion: Despite the earlier and more widespread use of antimicrobial and antiretroviral agents, neurologic conditions still occurred frequently in this cohort, with annual rates above 1.5 per 100 person-years for HIV dementia and sensory neuropathy. Sensory neuropathy seems to be increasing in incidence and HIV dementia declining slightly in this cohort. As the epidemic matures and more people with profound immunosuppression live longer, the overall incidence of HIV-related neurologic diseases can be expected to rise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:48:21