Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
D-VAL(22) CONTAINING HUMAN BIG ENDOTHELIN-1 ANALOG, [D-VAL(22)]BIG ET-1[16-38], INHIBITS THE ENDOTHELIN-CONVERTING ENZYME
Autore:
MORITA A; NOMIZU M; OKITSU M; HORIE K; YOKOGOSHI H; ROLLER PP;
Indirizzi:
UNIV SHIZUOKA,SCH FOOD & NUTR SCI,NUTR BIOCHEM LAB,52-1 YADA SHIZUOKA422 JAPAN NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,MED CHEM LAB BETHESDA MD20892
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 353, anno: 1994,
pagine: 84 - 88
SICI:
0014-5793(1994)353:1<84:DCHBEA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPLEEN FIBRINOLYTIC PROTEINASE; PHASE PEPTIDE-SYNTHESIS; CELLS; CONVERSION; ACID; PHOSPHORAMIDON; SECRETION; PLASMA; INVIVO;
Keywords:
ENDOTHELIN-1; ENDOTHELIN CONVERTING ENZYME; D-AMINO ACID; BIG ENDOTHELIN-1 ANALOG; PROTEASE INHIBITOR; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Morita et al., "D-VAL(22) CONTAINING HUMAN BIG ENDOTHELIN-1 ANALOG, [D-VAL(22)]BIG ET-1[16-38], INHIBITS THE ENDOTHELIN-CONVERTING ENZYME", FEBS letters, 353(1), 1994, pp. 84-88

Abstract

Endothelin converting enzyme (ECE) is essential for generation of thebiological effects of endothelin-1 (ET-1) from a precursor, big endothelin-1 (Big ET-1). We synthesized four analogs of human Big ET-1[16-38], substituted with single D-amino acids at P1, P2, P1' and P2' positions. ECE activity was determined using an ET-1 specific radioimmunoassay system. None of the D-amino acid containing Big ET-1 analogs were apparently cleaved by ECE, however, one of the synthetic peptides, [D-Val(22)]Big ET-1[16-38], strongly inhibited the ECE activity. Furthermore, when this D-Val(22) containing peptide was preadministrated to rat striatum, it was found to inhibit the dopamine release induced by Big ET-1. This result suggests that the D-Val(22) containing peptide inhibits the ECE activity in vivo. The D-Val(22) containing inhibitor offers hope of developing more potent and highly specific ECE inhibitors of therapeutic significance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:34:39