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Titolo:
ANXIOLYTIC EFFECT OF NITRIC-OXIDE SYNTHASE INHIBITORS MICROINJECTED INTO THE DORSAL CENTRAL GREY
Autore:
GUIMARAES FS; DEAGUIAR JC; DELBEL EA; BALLEJO G;
Indirizzi:
UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT PHARMACOL BR-14049 RIBEIRAO PRET BRAZIL UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT PHYSIOL BR-14049 RIBEIRAO PRET BRAZIL
Titolo Testata:
NeuroReport
fascicolo: 15, volume: 5, anno: 1994,
pagine: 1929 - 1932
SICI:
0959-4965(1994)5:15<1929:AEONSI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; INDUCED SEIZURES; RAT-BRAIN; L-NAME; GLUTAMATE; NEURONS; MECHANISMS; RECEPTORS; MESSENGER; RELEASE;
Keywords:
NITRIC OXIDE; NMDA; ANXIETY; DORSAL PERIAQUEDUCTAL GREY; NITRIC OXIDE SYNTHASE; ANXIOLYTIC; ANXIOGENIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
F.S. Guimaraes et al., "ANXIOLYTIC EFFECT OF NITRIC-OXIDE SYNTHASE INHIBITORS MICROINJECTED INTO THE DORSAL CENTRAL GREY", NeuroReport, 5(15), 1994, pp. 1929-1932

Abstract

NITRIC oxide synthase (NOS) accounts for most of the NADPH-diaphoraseneuronal activity in the brain. NADPH-diaphorase-positive neurones have been localized at the dorso-lateral part of the periaqueductal grey(FAG), a region related to anxiety. Microinjections of the NOS inhibitors L-NAME (10-200 nmol 0.5 mu l(-1)) and L-NOARG (10-100 nmol) at this site induced anxiolytic-like effects in the elevated plus maze. These effects, however, occurred only at a limited range of doses and thedose-effect curve had a bell shape, higher doses of both compounds tending to be anxiogenic. The anxiolytic effect of L-NAME was antagonized by a previous microinjection of L-arginine (50 nmol 0.5 mu l(-1)). These results suggest that NO may play a role in FAG neurotransmission involved in anxiety.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 11:25:42