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Titolo:
ONDANSETRON FAILS TO ATTENUATE A SCOPOLAMINE-INDUCED DEFICIT IN A STONE MAZE TASK
Autore:
BRATT AM; KELLY ME; DOMENEY AM; NAYLOR RJ; COSTALL B;
Indirizzi:
UNIV BRADFORD,SCH PHARM BRADFORD BD7 1DP W YORKSHIRE ENGLAND
Titolo Testata:
NeuroReport
fascicolo: 15, volume: 5, anno: 1994,
pagine: 1921 - 1924
SICI:
0959-4965(1994)5:15<1921:OFTAAS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
14-UNIT T-MAZE; 5-HT3 RECEPTORS; CEREBRAL-CORTEX; PERFORMANCE; RATS; ACQUISITION; HIPPOCAMPUS; RELEASE; SYSTEM; MEMORY;
Keywords:
STONE MAZE; SPATIAL MEMORY; SCOPOLAMINE; ONDANSETRON; 5-HT3 RECEPTOR ANTAGONISTS; HIPPOCAMPUS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Bratt et al., "ONDANSETRON FAILS TO ATTENUATE A SCOPOLAMINE-INDUCED DEFICIT IN A STONE MAZE TASK", NeuroReport, 5(15), 1994, pp. 1921-1924

Abstract

THE 5-HT, receptor antagonist ondansetron has previously been reported to improve cognition in the mouse, rat and marmoset in a variety of behavioural paradigms. The present study used the Stone maze to test the effect of ondansetron on the deficit caused by scopolamine in the performance of a highly complex spatial memory task in the rat. Ondansetron administered over a large dose range (1.0 ng kg(-1)-1.0 mu g kg(-1), i.p., b.d.) for a period of 10-15 days failed to attenuate the scopolamine deficit. Indeed at one dose level ondansetron (100 ng kg(-1),i.p., b.d.) administered in combination with scopolamine (0.5 mg kg(-1), i.p.) significantly potentiated the deficit, compared with the performance of rats receiving scopolamine alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:14:29