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Titolo:
SPECIFIC ASSOCIATION OF EPSTEIN-BARR-VIRUS WITH LYMPHOEPITHELIAL CARCINOMA AMONG TUMORS AND TUMOR-LIKE LESIONS OF THE SALIVARY-GLAND
Autore:
CHAN JKC; YIP TTC; TSANG WYW; POON YF; WONG CSC; MA VWS;
Indirizzi:
QUEEN ELIZABETH HOSP,DEPT PATHOL HONG KONG HONG KONG QUEEN ELIZABETH HOSP,DEPT RADIOTHERAPY ONCOL HONG KONG HONG KONG
Titolo Testata:
Archives of pathology and laboratory medicine
fascicolo: 10, volume: 118, anno: 1994,
pagine: 994 - 997
SICI:
0003-9985(1994)118:10<994:SAOEWL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NASOPHARYNGEAL CARCINOMA; INSITU HYBRIDIZATION; THYMIC CARCINOMA; PAROTID-GLAND; VIRAL GENOME; UNDIFFERENTIATED CARCINOMA; EXPRESSION; DNA; ADENOCARCINOMA; BIOPSIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
J.K.C. Chan et al., "SPECIFIC ASSOCIATION OF EPSTEIN-BARR-VIRUS WITH LYMPHOEPITHELIAL CARCINOMA AMONG TUMORS AND TUMOR-LIKE LESIONS OF THE SALIVARY-GLAND", Archives of pathology and laboratory medicine, 118(10), 1994, pp. 994-997

Abstract

The Epstein-Barr virus (EBV)-encoded RNAs in situ localization procedure is a convenient, highly sensitive, and highly specific technique that is applicable to routinely fixed, paraffin-embedded tissue sections; this technique can be used for the study of the association and, hence, the possible causal role of EBV in tumors. This study was performed to elucidate whether EBV plays a role in the pathogenesis of tumorsthat arise in the salivary glands, since the salivary gland is known to be a reservoir for EBV replication. Cases that were selected included 61 examples of various benign and malignant neoplasms, as well as tumorlike conditions of the major and minor salivary glands. Only the five cases of lymphoepithelial carcinoma (so-called malignant lymphoepithelial lesion) and the single case of metastatic nasopharyngeal undifferentiated carcinoma showed staining with EBV-encoded RNAs, whereas negative findings were found in all of the other cases. In the cases with positive results, all of the neoplastic epithelial cells showed strong nuclear signals, but the lymphoid cells were negative. The consistent association of EBV with lymphoepithelial carcinoma of the salivarygland suggests that the virus probably plays a causal role in this tumor, at least in the Asian population, whereas there is no evidence for a causal role of EBV in other primary tumors of the salivary gland.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 22:31:31