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Titolo:
AZOLE-RESISTANT CANDIDA-ALBICANS - REPORT OF 2 CASES OF RESISTANCE TOFLUCONAZOLE AND REVIEW
Autore:
WHITE A; GOETZ MB;
Indirizzi:
SEPULVEDA VA MED CTR,DEPT MED,16111 PLUMMER ST SEPULVEDA CA 91343 SEPULVEDA VA MED CTR,DEPT MED SEPULVEDA CA 91343 UNIV CALIF LOS ANGELES,SAN FERNANDO VALLEY PROGRAM SEPULVEDA CA 00000 UNIV CALIF LOS ANGELES,SCH MED LOS ANGELES CA 00000
Titolo Testata:
Clinical infectious diseases
fascicolo: 4, volume: 19, anno: 1994,
pagine: 687 - 692
SICI:
1058-4838(1994)19:4<687:AC-RO2>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-POSITIVE PATIENTS; ORAL CANDIDIASIS; DOUBLE-BLIND; OROPHARYNGEAL CANDIDIASIS; AIDS PATIENTS; CLOTRIMAZOLE TREATMENT; GENETIC SIMILARITY; VAGINITIS PATIENTS; INFECTED PATIENTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
87
Recensione:
Indirizzi per estratti:
Citazione:
A. White e M.B. Goetz, "AZOLE-RESISTANT CANDIDA-ALBICANS - REPORT OF 2 CASES OF RESISTANCE TOFLUCONAZOLE AND REVIEW", Clinical infectious diseases, 19(4), 1994, pp. 687-692

Abstract

We report the course of oropharyngeal infection by Candida albicans that was refractory to treatment with fluconazole in two patients infected by the human immunodeficiency virus (HIV). We also review the epidemiology of C. albicans with decreased in vitro and in vivo susceptibility to azole antifungal agents, the significance of such isolates, the known mechanisms by which C. albicans may become less susceptible toazole antifungal agents, and the efficacy of various treatments for mucosal candidiasis. The occurrence in HIV-infected patients of mucosalcandidiasis that is refractory to therapy with fluconazole and is dueto C. albicans that demonstrates decreased in vitro susceptibility tofluconazole has been reported since 1990. Following the release of miconazole and ketoconazole in the late 1970s, C. albicans with decreased in vitro susceptibility to these agents was isolated from patients with chronic mucocutaneous candidiasis who required repeated and prolonged courses of therapy. Subsequently, C. albicans with decreased in vitro susceptibility to ketoconazole, clotrimazole, and itraconazole hasbeen isolated from HIV-infected patients. Recent reports of the sexual and nosocomial transmission of wildtype C. albicans indicate the possibility of future person-to-person transmission of C. albicans with decreased in vitro susceptibility to azole antifungal agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:39:18