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Titolo:
NEW MAGNETIC-RESONANCE-IMAGING TECHNIQUES FOR THE DETECTION OF BREAST-CANCER
Autore:
ORANGKHADIVI K; PIERCE BL; OLLOM CM; FLOYD LJ; SIEGLE RL; WILLIAMS RF;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,CTR RES IMAGING,DEPT RADIOL,7703 FLOYD CURL DR SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,CTR RES IMAGING,DEPT RADIOL SAN ANTONIO TX 78284
Titolo Testata:
Breast cancer research and treatment
fascicolo: 1, volume: 32, anno: 1994,
pagine: 119 - 135
SICI:
0167-6806(1994)32:1<119:NMTFTD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERPARAMAGNETIC IRON-OXIDE; ACUTE MYOCARDIAL-INFARCTION; GADOLINIUM-DTPA COMPLEX; MRI CONTRAST AGENT; MONOCLONAL-ANTIBODY; PROTON RELAXATION; HUMAN TUMORS; NMR; PARTICLES; CARCINOMA;
Keywords:
MAGNETIC RESONANCE IMAGING (MRI); MAGNETIC RESONANCE MAMMOGRAPHY (MRM); SITE-SPECIFIC MR CONTRAST AGENTS; BREAST CANCER TARGETED MR IMAGING; GADOLINIUM-MELANIN POLYMER (GMP) CONTRAST AGENTS; MR MAGNETOPHARMACEUTICAL AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
91
Recensione:
Indirizzi per estratti:
Citazione:
K. Orangkhadivi et al., "NEW MAGNETIC-RESONANCE-IMAGING TECHNIQUES FOR THE DETECTION OF BREAST-CANCER", Breast cancer research and treatment, 32(1), 1994, pp. 119-135

Abstract

The importance of contrast agents in enhancing diagnoses from magnetic resonance images has been established in numerous cases. However, the development of a potent tissue-specific contrast agent, as a sensitive probe for early detection and investigation of the physiological characteristics of a tumor, has not yet been realized in MR imaging (MRI). In nuclear scintigraphy the technique has been demonstrated; however, the poor spacial resolution inherent to the modality and the substantial dose of radioactivity administered to the patient has hindered its widespread use. This article will review the different classes of contrast agents in MRI, with special focus on the strategies involved in the development of targeted tissue-specific MRI contrast agents for the early detection of breast cancer. The features of a new class of contrast agents for targeted MR imaging will be described. Gadolinium-containing melanin polymers (GMP's) have been synthesized as MR contrast agents in our laboratory. These GMP's demonstrate significantly higher relaxivities than any other paramagnetic contrast agents reported; consequently, they are extremely effective contrast enhancing, imagingagents by themselves. The successful coupling of these potent GMP's to a monoclonal antibody specific for breast carcinoma, the 323/A3 monoclonal antibody, suggests that in vivo tissue-specific MR imaging, at the receptor level, will become feasible in the near future.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:37:48