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Titolo:
RADIO-IMMUNOTHERAPY DOSIMETRY WITH SPECIAL EMPHASIS ON SPECT QUANTIFICATION AND EXTRACORPOREAL IMMUNO-ADSORPTION
Autore:
STRAND SE; LJUNGBERG M; TENNVALL J; NORRGREN K; GARKAVIJ M;
Indirizzi:
UNIV LUND HOSP,DEPT RADIAT PHYS,LASARETTET S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT ONCOL S-22185 LUND SWEDEN
Titolo Testata:
Medical & biological engineering & computing
fascicolo: 5, volume: 32, anno: 1994,
pagine: 551 - 561
SICI:
0140-0118(1994)32:5<551:RDWSEO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOLABELED MONOCLONAL-ANTIBODIES; SCATTER CORRECTION METHOD; TUMOR UPTAKE; MONTE-CARLO; RADIONUCLIDE THERAPY; QUANTITATIVE SPECT; GUIDED IRRADIATION; SOLID TUMORS; ANTI-CEA; RADIOIMMUNOTHERAPY;
Keywords:
ABSORBED DOSE; ATTENUATION CORRECTION; EXTRACORPOREAL IMMUNO-ADSORPTION; QUANTIFICATION; RADIO-IMMUNOTHERAPY; SCATTER; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
133
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Strand et al., "RADIO-IMMUNOTHERAPY DOSIMETRY WITH SPECIAL EMPHASIS ON SPECT QUANTIFICATION AND EXTRACORPOREAL IMMUNO-ADSORPTION", Medical & biological engineering & computing, 32(5), 1994, pp. 551-561

Abstract

Results from therapeutic trials with radiolabelled monoclonal antibodies are difficult to compare, because of lack of accurate macroscopic and microscopic dosimetry for both tumours and normal tissues. Requirements for such a dosimetry are covered in the paper. Accurate in vivo dosimetric measurement techniques for verification of calculated absorbed doses are also needed to verify treatment planning. In the review,important topics related to dosimetry in therapeutic trials in RIT are covered, such as, absorbed-dose calculations and activity-quantification techniques for planar imaging and SPECT. The latter is particularly discussed, including a summary of different correction techniques. Absorbed-dose calculations and treatment-planning techniques are also discussed. possible ways extracorporeal immuno-adsorption. The review could form the basis of the development of future treatment-planning protocols and for dosimetry calculations in radio-immunotherapy, considering some of the most important parameters for approaching an accurate in vivo dosimetry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 16:24:37