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Titolo:
ON THE ABSORPTION OF DRUGS USING CHRONIC DOG ILEAL LOOP METHOD
Autore:
KUKAN M; BEZEK S; TRNOVEC T; GABAUER I; STYK J;
Indirizzi:
SLOVAK ACAD SCI,INST EXPTL PHARMACOL,DUBRAVSKA CESTA 9 BRATISLAVA 84216 SLOVAKIA SLOVAK ACAD SCI,HEART RES INST BRATISLAVA 84216 SLOVAKIA
Titolo Testata:
Methods and findings in experimental and clinical pharmacology
fascicolo: 6, volume: 16, anno: 1994,
pagine: 437 - 442
SICI:
0379-0355(1994)16:6<437:OTAODU>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL-ABSORPTION; STOBADINE; EXTRACTION; SERUM; RAT;
Keywords:
DRUG ABSORPTION; CHRONIC DOG ILEAL LOOP METHOD; PENTACAINE; STOBADINE; ACETYLSALICYLIC ACID; ANTACIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Kukan et al., "ON THE ABSORPTION OF DRUGS USING CHRONIC DOG ILEAL LOOP METHOD", Methods and findings in experimental and clinical pharmacology, 16(6), 1994, pp. 437-442

Abstract

The absorption rate of three model drugs, i.e., pentacaine (highly lipophilic), stobadine (moderately lipophilic) and acetylsalicylic acid (hydrophilic), was studied using the chronic dog ileal loop method. The drugs were dissolved either in 0.9% unbuffered solution of NaCl or in antacid mixture. When using 0.9% NaCl, the half-lives of absorption (t(1/2)(dis)) of pentacaine and stobadine were (mean +/- SD) 23.2 +/- 7.8 min and 20.8 +/- 7.2 min, respectively. For stobadine a good agreement was found between its t(1/2) (dis) from the ileum and its absorption half-life determined from blood concentrations after oral administration to dogs. The absorption of acetylsalicylic acid accounted for only 10-20% of the dose introduced into the loop over 45 min; thus, a reliable value of t(1/2) (dis) could not be determined. The administration of unbuffered solution of NaCl into the loop was accompanied by rapid increase of pH from,n acidic to basic value. The antacid mixture failed to affect the absorption rate of the drugs studied. Sampling from the ileum was limited to 35-55 min due to rapid absorption of water. These results suggest that: 1) measurement of the absorption rate of some drugs, e.g., stobadine, by using the chronic dog ileal loop method may adequately predict their absorption rate after peroral administration to the dog, 2) interactions of antacids with drug absorption in the ileum may not play a significant role because of the strong buffering capacity of the ileum, and 3) rapid absorption of water from the ileum does not allow to reliably determine the value of tm (dis) for slowly absorbed drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:19:48