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Titolo:
INCREASED SERUM LEVELS OF ICAM-1, ELAM-1 AND TNF-ALPHA IN INFLAMMATORY DISORDERS OF THE PERIPHERAL NERVOUS-SYSTEM
Autore:
MUSSO AM; ZANUSSO GL; BONAZZI ML; TOMELLERI G; BONETTI B; MORETTO G; VIO M; MONACO S;
Indirizzi:
UNIV VERONA,IST NEUROL I-37100 VERONA ITALY UNIV VERONA,IST CHIM & MICROSCOPIA CLIN I-37100 VERONA ITALY
Titolo Testata:
Italian journal of neurological sciences
fascicolo: 6, volume: 15, anno: 1994,
pagine: 267 - 271
SICI:
0392-0461(1994)15:6<267:ISLOIE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; CIRCULATING ICAM-1; CEREBROSPINAL-FLUID; MULTIPLE-SCLEROSIS; ENDOTHELIAL-CELLS; IMMUNE-SYSTEM; MACROPHAGES; BARRIER;
Keywords:
GUILLAIN-BARRE SYNDROME; CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULOPATHY; CRYOGLOBULINEMIC NEUROPATHY; ICAM-1; ELAM-1; TNF-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Musso et al., "INCREASED SERUM LEVELS OF ICAM-1, ELAM-1 AND TNF-ALPHA IN INFLAMMATORY DISORDERS OF THE PERIPHERAL NERVOUS-SYSTEM", Italian journal of neurological sciences, 15(6), 1994, pp. 267-271

Abstract

Endothelial intercellular adhesion molecule-1 (ICAM-1) and glycoprotein E-selectin (ELAM-1) allow the homing of leukocytes to inflammation sites. A circulating form of ICAM-1 markedly increases in inflammatoryCNS disorders. In the present study, the serum levels of ICAM-1, ELAM-1 and tumor necrosis factor-alpha (TNF-alpha) were measured in patients with acute (AIDP) and chronic (CIDP) inflammatory demyelinating polyneuropathies and cryoglobulinemic neuropathy (CGN). Immunoenzymometric assays revealed increased sICAM-1 levels in some of these patients; furthermore, high titres of ELAM-1 and TNF-alpha were detected in two patients with AIDP and one patient with CGN. Our data extend previous observations on inflammatory PNS disorders by showing that, in addition to ICAM-1, ELAM-1 also represents a useful marker of endothelial activation and that, taken together, the two molecules may serve as an indicator of specific pathogenetic mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:39:31