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Titolo:
ANTIVIRAL AND IMMUNOMODULATING INHIBITORS OF EXPERIMENTALLY-INDUCED PUNTA-TORO VIRUS-INFECTIONS
Autore:
SIDWELL RW; HUFFMAN JH; BARNARD DL; SMEE DF; WARREN RP; CHIRIGOS MA; KENDE M; HUGGINS J;
Indirizzi:
UTAH STATE UNIV,INST ANTIVIRAL RES LOGAN UT 84322 USA,MED RES INST INFECT DIS,DIV VIROL FT DETRICK MD 21702
Titolo Testata:
Antiviral research
fascicolo: 2, volume: 25, anno: 1994,
pagine: 105 - 122
SICI:
0166-3542(1994)25:2<105:AAIIOE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-BETA INTERFERON; PHLEBOVIRUS INFECTIONS; RIBAVIRIN; MICE; 3-DEAZAGUANINE; INDUCTION; AGENT; RNA;
Keywords:
PUNTA TORO VIRUS; ANTIVIRAL; RIBAVIRIN ANALOG; IMMUNOMODULATOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Sidwell et al., "ANTIVIRAL AND IMMUNOMODULATING INHIBITORS OF EXPERIMENTALLY-INDUCED PUNTA-TORO VIRUS-INFECTIONS", Antiviral research, 25(2), 1994, pp. 105-122

Abstract

A major component of a US Army Medical Research and Development Command-supported program to discover and develop new drugs for the treatment of Rift Valley fever, sandfly fever, and Crimean-Congo hemorrhagic fever has been to study candidate test materials against hepatotropic infections of C57BL/6 mice induced by the related but less biohazardous Punta Toro virus (PTV). The effects of 75 compounds, some of which were considered immunomodulators in their primary mechanism of activity, were studied in the PTV infection model. Of these, ribavirin, ribamidine, ribavirin 2',3',5'-triacetate, tiazofurin, tiazofurin-5'-monophosphate, tiazofurin-2',3',5'-triacetate, selenazofurin, pyrazofurin, 3-deazaguanine, and 3-deazaguanosine were considered significantly inhibitory, acting against the infection by a direct antiviral (non-immunomodulatory) fashion. These compounds had therapeutic indices (TI) ranging from greater than or equal to 5 to 65, using increased survivors asthe evaluation parameter. Immunomodulators considered significantly inhibitory to this infection were poly (ICLC), ampligen, human recombinant interferon-alpha-A/D, MVE-1, MVE-2, AM-3, AM-5, mannozym, bropirimine, CL246,738, phenyleneamine, and 7-thia-8-oxoguanosine. Utilizing increased survivor numbers as measure of activity, these inhibitors hadTI ranging from greater than or equal to 16 to 1000. Other antiviral effects exerted by the active compounds included reduction of hepatic icterus, lowered serum glutamic oxaloacetic and pyruvic acid transaminases, and inhibition of recoverable serum and liver virus titers. The active immunomodulators were significantly effective when therapy was initiated as late as 48 h after virus inoculation, at a time when clinical signs of the PTV disease were being manifested in the animal.

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Documento generato il 11/08/20 alle ore 03:02:58