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Titolo:
THE ROLE OF POSTOPERATIVE IRRADIATION IN THE TREATMENT OF OLIGODENDROGLIOMA
Autore:
GANNETT DE; WISBECK WM; SILBERGELD DL; BERGER MS;
Indirizzi:
UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT RADIAT ONCOL,1501 N CAMPBELL AVE TUCSON AZ 85724 UNIV WASHINGTON,DEPT RADIAT ONCOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT NEUROSURG SEATTLE WA 98195
Titolo Testata:
International journal of radiation oncology, biology, physics
fascicolo: 3, volume: 30, anno: 1994,
pagine: 567 - 573
SICI:
0360-3016(1994)30:3<567:TROPII>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; RADIOTHERAPY; SURVIVAL;
Keywords:
BRAIN NEOPLASM; OLIGODENDROGLIOMA; OUTCOME; RADIATION THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Gannett et al., "THE ROLE OF POSTOPERATIVE IRRADIATION IN THE TREATMENT OF OLIGODENDROGLIOMA", International journal of radiation oncology, biology, physics, 30(3), 1994, pp. 567-573

Abstract

Purpose: Controversy regarding the role of adjuvant radiation therapyfor the treatment of oligodendroglioma continues to exist. To better define the utility of postoperative irradiation for this tumor, the experience at the University of Washington was retrospectively examined. Methods and Materials: The histologic samples of 63 patients given the diagnosis of oligodendroglioma were reviewed by a panel of neuropathologists and 41 were classified as pure oligodendroglioma. The two treatment groups included 14 patients treated with surgery only and 27 who received surgery and postoperative radiation and were analyzed usingunivariate and multivariate analysis with respect to prognostic factors, freedom from relapse, and survival. Results: Univariate statistical analysis of 14 clinical variables showed that a poorer prognosis wasassociated in patients with high cell density (p = .008), necrosis (p= .017), hemiparesis (p = .026), and papilledema (p =.091), while patients presenting with seizures had a better prognosis (p = .0096). Multivariate analysis showed necrosis (p = .001) and hemiparesis (p = .02) to be associated with decreased survival. Multivariate and univariate analysis of the treatment groups found them to be homogenous with respect to prognostic factors. Survival times were significantly longer in the group treated with postoperative irradiation (median survival time 84 vs. 47 months, p = .032). The 5 and 10 year survival rates were83% and 46%, respectively, for the irradiated patients compared with 51% and 36% for those treated with surgery alone. Freedom from tumor recurrence times were also longer in irradiated patients (median relapse free time 79 vs. 42 months, p = .01). Conclusion: Based on the results of this study, we recommend continuing the practice of treating oligodendroglioma with postresection irradiation until a prospective multicenter clinical trial is conducted to thoroughly evaluate the role ofpostoperative irradiation in the treatment of this tumor.

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Documento generato il 30/11/20 alle ore 17:58:24