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Titolo:
SYNERGY BETWEEN DEXAMETHASONE AND INTERLEUKIN-5 FOR THE INDUCTION OF MAJOR HISTOCOMPATABILITY COMPLEX CLASS-II EXPRESSION BY HUMAN PERIPHERAL-BLOOD EOSINOPHILS
Autore:
GUIDA L; OHEHIR RE; HAWRYLOWICZ CM;
Indirizzi:
ST MARYS HOSP,SCH MED,DEPT IMMUNOL,NORFOLK PL LONDON W2 1PG ENGLAND ST MARYS HOSP,SCH MED,DEPT IMMUNOL LONDON W2 1PG ENGLAND
Titolo Testata:
Blood
fascicolo: 8, volume: 84, anno: 1994,
pagine: 2733 - 2740
SICI:
0006-4971(1994)84:8<2733:SBDAIF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; HLA-DR; HUMAN-MONOCYTES; GM-CSF; GENOMIC STRUCTURE; UP-REGULATION; GLUCOCORTICOIDS; ANTIGEN; CELLS; ASTHMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
L. Guida et al., "SYNERGY BETWEEN DEXAMETHASONE AND INTERLEUKIN-5 FOR THE INDUCTION OF MAJOR HISTOCOMPATABILITY COMPLEX CLASS-II EXPRESSION BY HUMAN PERIPHERAL-BLOOD EOSINOPHILS", Blood, 84(8), 1994, pp. 2733-2740

Abstract

The hematopoietic growth factors interleukin-3 (IL-3), IL-5. and granulocyte-macrophage colony-stimulating factor (GM-CSF) regulate the survival, maturation, and activation of eosinophils. Corticosteroids in contrast have a negative effect both on the hematopoietic process and the function of eosinophils. We have unexpectedly observed synergy between IL-5 and glucocorticoids such as dexamethasone and hydrocortisone for induction of the MHC class II antigens HLA-DR and HLA-DP on eosinophils isolated from human blood. Similarly glucocorticoids enhanced GM-CSF and IL-3, but not interferon gamma (IFN gamma), induced expression of these antigens. Expression of a third MHC class II molecule, HLA-DQ, was not induced on eosinophils by any of the cytokines alone, but in one of three donors tested, IL-3 plus dexamethasone induced high levels of expression. Although cytokine-induced exprc!ssion of the accessory molecule intercellular adhesion molecule 1 (ICAM-1) was partiallyinhibited by glucocorticoids, cytokine- and dexamethasone-treated eosinophils presented antigen more efficiently to a hemagglutinin peptide-specific T-cell clone than eosinophils treated with cytokine alone. These results highlight a potential new role for endogenous or exogenous glucocorticoid hormones in enhancing MHC class II expression by eosinophils. (C) 1994 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 10:24:20