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Titolo:
EFFECTS OF SOME NATURALLY-OCCURRING PROSTANOIDS AND SOME CYCLOOXYGENASE INHIBITORS ON THE CONTRACTILITY OF THE HUMAN LOWER UTERINE SEGMENT IN-VITRO
Autore:
CRANKSHAW DJ; DYAL R;
Indirizzi:
MCMASTER UNIV,DEPT OBSTET & GYNECOL HAMILTON L8N 3Z5 ON CANADA
Titolo Testata:
Canadian journal of physiology and pharmacology
fascicolo: 8, volume: 72, anno: 1994,
pagine: 870 - 874
SICI:
0008-4212(1994)72:8<870:EOSNPA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MYOMETRIUM; INVITRO CHARACTERIZATION; PROSTAGLANDINS; PREGNANCY; RECEPTORS; TERM; UTERUS; RAT;
Keywords:
PROSTAGLANDINS; INDOMETHACIN; MYOMETRIUM; HUMAN; UTERINE CONTRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Crankshaw e R. Dyal, "EFFECTS OF SOME NATURALLY-OCCURRING PROSTANOIDS AND SOME CYCLOOXYGENASE INHIBITORS ON THE CONTRACTILITY OF THE HUMAN LOWER UTERINE SEGMENT IN-VITRO", Canadian journal of physiology and pharmacology, 72(8), 1994, pp. 870-874

Abstract

The contractility of strips of human lower segment myometrium obtained from elective cesarean section performed at term of pregnancy was studied in vitro. The effects of indomethacin and tiaprofen upon spontaneous contractile activity were examined. Concentration-effect curves for PGD(2), PGE(2), PGF(2 alpha), 6-keto-PGE(1), and 6-keto-PGF(1 alpha) were constructed in the presence of indomethacin. Neither indomethacin nor tiaprofen in concentrations up to 100 mu mol/L had any effect upon spontaneous activity. Contractions were induced by the prostanoidswith the following mean EC(50) values: PGE(2), 13 nM; PGF(2 alpha), 250 nM; PGD(2), 790 nM; both 6-keto-PGF(1 alpha) and 6-keto-PGE(1) werewithout effect in concentrations up to 30 mu mol/L. In some tissues PGE(2) inhibited spontaneous activity with a mean IC50 of 100 nM. No other prostanoid tested caused inhibition under any circumstance. The marked potency differences between the natural prostanoids is an important parameter to consider when assessing their relative contributions to the process of parturition and the design of new therapeutic agents for the management of preterm labour.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:50:41