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Titolo:
B-CELLS OF AGING RATS - IMPAIRED STIMULUS-SECRETION COUPLING BUT NORMAL SUSCEPTIBILITY TO ADVERSE-EFFECTS OF A DIABETIC STATE
Autore:
INOUE K; NORGREN S; LUTHMAN H; MOLLER C; GRILL V;
Indirizzi:
KAROLINSKA HOSP,DEPT MOL MED S-17176 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT MOL MED S-17176 STOCKHOLM SWEDEN UNIV TRONDHEIM,DEPT MED,ENDOCRINE SECT TRONDHEIM NORWAY
Titolo Testata:
Metabolism, clinical and experimental
fascicolo: 3, volume: 46, anno: 1997,
pagine: 242 - 246
SICI:
0026-0495(1997)46:3<242:BOAR-I>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED INSULIN-SECRETION; ISOLATED PANCREATIC-ISLETS; LONG-TERM EXPOSURE; BETA-CELL; MESSENGER-RNA; GLUCOSE; HYPERGLYCEMIA; RELEASE; DESENSITIZATION; LANGERHANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
K. Inoue et al., "B-CELLS OF AGING RATS - IMPAIRED STIMULUS-SECRETION COUPLING BUT NORMAL SUSCEPTIBILITY TO ADVERSE-EFFECTS OF A DIABETIC STATE", Metabolism, clinical and experimental, 46(3), 1997, pp. 242-246

Abstract

A diabetic state impairs B-cell function and survival, We tested whether the negative effects are exacerbated by the aging process. Islets were isolated from old (63.3 +/- 2.3 weeks) and young (11.3 +/- 0.5 weeks) inbred Wistar rats, Age did not affect DNA and insulin content, yet both glucose-induced (27.8 mmol/L) and arginine-induced induced (10mmol/L) insulin responses in old islets were significantly reduced, Islets were transplanted under the kidney capsule of recipients that were either nondiabetic or severely diabetic after streptozotocin (STZ) treatment (blood glucose > 20 mmol/L). Following 8 weeks' transplantation to nondiabetic recipients, perfused kidneys with grafts of old islets exhibited the same insulin responses to glucose as grafts of youngislets. However, responses to arginine were reduced in grafts of old islets (28 +/- 4 mu U/min) relative to grafts of young islets, (70 +/-18 mu U/min, P < .05). Insulin mRNA content was similar in grafts of old islets and grafts of young islets. Following 8 weeks' transplantation to diabetic recipients, 27.8 mmol/L glucose failed to induce insulin secretion in grafts of old islets and grafts of young islets alike,whereas arginine-induced insulin secretion was unaffected in grafts of old islets but reduced in grafts of young islets, Insulin mRNA content was reduced to a similar extent by the diabetic state (to 28% in grafts of old islets and to 27% in grafts of young islets grafts in nondiabetic recipients). We conclude that aging, although leading to impaired stimulus-secretion coupling, does not increase susceptibility to the negative effects of a diabetic state on B-cell function as presently tested. Copyright (C) 1997 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:35:32