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Titolo:
EPIDERMAL CYTOKINES AND SKIN SENSITIZATION HAZARD
Autore:
CUMBERBATCH M; KIMBER I;
Indirizzi:
ZENECA CENT TOXICOL LAB,ALDERLEY PK MACCLESFIELD SK10 4TJ CHESHIRE ENGLAND
Titolo Testata:
Toxicology in vitro
fascicolo: 4, volume: 8, anno: 1994,
pagine: 685 - 687
SICI:
0887-2333(1994)8:4<685:ECASSH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NODE DENDRITIC CELLS; LANGERHANS CELLS; IMMUNE-RESPONSES; EXPRESSION; MATURATION; IL-1-BETA; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
M. Cumberbatch e I. Kimber, "EPIDERMAL CYTOKINES AND SKIN SENSITIZATION HAZARD", Toxicology in vitro, 8(4), 1994, pp. 685-687

Abstract

The induction phase of skin sensitization is associated with the passage of antigen-bearing Langerhans cells (LC) from the epidermis to thedraining lymph nodes. Recent investigations have revealed that the induction of LC migration following topical sensitization is dependent on tumour necrosis factor alpha (TNF-alpha), an epidermal cytokine. While in transit to the lymph nodes LC are subject to both phenotypic andfunctional maturation which, by analogy with in vitro studies, is also effected by epidermal cytokines (granulocyte/macrophage colony-stimulating factor, GM-CSF and interleukin-1, IL-1). It is now apparent that Langerhans cell function, the induction of cutaneous immune responses and effective sensitization are dependent on the availability of such cytokines and that contact allergens are able to provoke their production by keratinocytes and by Langerhans cells themselves. The development of screening strategies for the evaluation of skin sensitization potential as a function of epidermal cytokine production is discussed.

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Documento generato il 27/11/20 alle ore 02:03:46