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Titolo:
CIGARETTE-SMOKING AND PANCREAS CANCER - A CASE-CONTROL STUDY BASED ONDIRECT INTERVIEWS
Autore:
SILVERMAN DT; DUNN JA; HOOVER RN; SCHIFFMAN M; LILLEMOE KD; SCHOENBERG JB; BROWN LM; GREENBERG RS; HAYES RB; SWANSON GM; WACHOLDER S; SCHWARTZ AG; LIFF JM; POTTERN LM;
Indirizzi:
NCI,DIV CANC ETIOL,EPIDEMIOL & BIOSTAT PROGRAM,EXECUT PLAZA N,RM 415 BETHESDA MD 20892 UNIV BIRMINGHAM,CANC RES CAMPAIGN,TRIALS UNIT BIRMINGHAM W MIDLANDS ENGLAND JOHNS HOPKINS UNIV,SCH MED,DEPT SURG BALTIMORE MD 21205 NEW JERSEY STATE DEPT HLTH,SPECIAL EPIDEMIOL PROGRAM TRENTON NJ 00000 EMORY UNIV,SCH PUBL HLTH,DIV EPIDEMIOL ATLANTA GA 00000 MICHIGAN STATE UNIV,COLL HUMAN MED E LANSING MI 48824 UNIV PITTSBURGH,SCH MED,DEPT CLIN EPIDEMIOL & FAMILY MED PITTSBURGH PA 00000
Titolo Testata:
Journal of the National Cancer Institute
fascicolo: 20, volume: 86, anno: 1994,
pagine: 1510 - 1516
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAST MEDICAL HISTORY; RISK-FACTORS; BEVERAGE CONSUMPTION; COFFEE CONSUMPTION; ALCOHOL; TOBACCO; DIET; MORTALITY; CARCINOMA; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
D.T. Silverman et al., "CIGARETTE-SMOKING AND PANCREAS CANCER - A CASE-CONTROL STUDY BASED ONDIRECT INTERVIEWS", Journal of the National Cancer Institute, 86(20), 1994, pp. 1510-1516

Abstract

Background: Cigarette smoking is the most consistently reported risk factor for pancreas cancer, yet the dose-response relationship in manypancreas cancer studies is weak. Because of the poor prognosis for pancreas cancer, many case-control studies have been based largely on interviews with proxy respondents, who are known to report less reliableinformation on detailed smoking habits than original subjects. Purpose: Our purpose was to evaluate cigarette smoking as a risk factor for pancreas cancer based on data obtained only from direct interviews andto estimate the effects of quitting smoking and of switching from nonfiltered to filtered cigarettes on risk. Our objective also was to estimate the contribution of cigarette smoking toward explaining the higher pancreas cancer incidence experienced by black Americans compared with white Americans. Methods: A population-based, case-control study of pancreas cancer was conducted during 1986-1989 in Atlanta, Ga., Detroit, Mich., and 10 counties in New Jersey. Direct interviews were successfully completed with 526 case patients and 2153 control subjects aged 30-79 years, making this the largest population-based, case-controlstudy of pancreas cancer to date based only on direct interviews. Results: Cigarette smokers had a significant, 70% increased risk of pancreas cancer compared with the risk in nonsmokers. A significant, positive trend in risk with increasing duration smoked was apparent (P<.0001), with long-term (greater than or equal to 40 years) smokers experiencing a modest 2.1-fold risk. We also observed a negative trend in riskwith increasing years quit smoking. Smokers who quit for more than 10years experienced about a 30% reduction in risk relative to current smokers; quitters of 10 years or less experienced no risk reduction. Switching from nonfiltered to filtered cigarettes did not appear to decrease risk. Compared with nonsmokers, subjects who smoked only filteredcigarettes had a 50% elevated risk and those who smoked only nonfiltered cigarettes had a 40% elevated risk. The proportion of pancreas cancer attributable to cigarette smoking was 29% in blacks and 26% in whites. Conclusions: The relationship between cigarette smoking and pancreas cancer risk is likely to be causal, despite the weakness of the dose-response data. Long-term smoking cessation clearly reduces risk, whereas switching from nonfiltered to filtered cigarettes may not be beneficial. Cigarette smoking appears to explain little of the excess pancreas cancer risk experienced by blacks. Implications: Elimination of cigarette smoking would eventually prevent approximately 27% of pancreas cancer, saving 6750 lives in the United States annually.

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Documento generato il 04/07/20 alle ore 05:28:04