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Titolo:
LOW CSF 5-HIAA CONCENTRATIONS AND SEVERE AGGRESSION AND IMPAIRED IMPULSE CONTROL IN NONHUMAN-PRIMATES
Autore:
MEHLMAN PT; HIGLEY JD; FAUCHER I; LILLY AA; TAUB DM; VICKERS J; SUOMI SJ; LINNOILA M;
Indirizzi:
LAB ANIM BREEDERS & SERV,DIV PRIMATE BREEDING BEHAV,POB 557 YEMASSEE SC 29945 US FDA ROCKVILLE MD 20857 NICHHD,CTR ANIM,COMPARAT ETHOL LAB POOLESVILLE MD 00000 NIAAA,DIV INTRAMURAL CLIN & BIOL RES,CLIN STUDIES LAB BETHESDA MD 20892
Titolo Testata:
The American journal of psychiatry
fascicolo: 10, volume: 151, anno: 1994,
pagine: 1485 - 1491
SICI:
0002-953X(1994)151:10<1485:LC5CAS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; DISRUPTIVE BEHAVIOR DISORDERS; DNA HYBRIDIZATION EVIDENCE; BIOGENIC-AMINE METABOLISM; 5-HYDROXYINDOLEACETIC ACID; RHESUS-MONKEYS; HOMOVANILLIC-ACID; SEROTONIN METABOLISM; VIOLENT OFFENDERS; PLASMA-CORTISOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
80
Recensione:
Indirizzi per estratti:
Citazione:
P.T. Mehlman et al., "LOW CSF 5-HIAA CONCENTRATIONS AND SEVERE AGGRESSION AND IMPAIRED IMPULSE CONTROL IN NONHUMAN-PRIMATES", The American journal of psychiatry, 151(10), 1994, pp. 1485-1491

Abstract

Objective: The purpose of this study was to examine the relationship between behavior and serotonin by using a nonhuman primate model of aggression and impulse control. Method: During a routine capture and medical examination, 26 adolescent male rhesus macaques (Macaca mulatta) were selected as subjects from a free-ranging population of 4,500 rhesus monkeys inhabiting a 475-acre sea island. Physiological data were obtained front 22-23 of the subjects. Blood and CSF samples were obtained, and each subject was fitted with a radio transmitter collar for rapid location. The subjects were released into their social groups, andquantitative behavioral observations were made over a 3-month period. Results: CSF 5-hydroxyindoleacetic acid (5-HIAA) concentrations were inversely correlated with ''escalated'' aggression, i.e., a measure ofmore intense or severe aggression as defined by the ratio of chases and Physical assaults to all aggressive acts. CSF 5-HIAA concentrationswere significantly lower in those subjects who showed evidence of physical wounding than in subjects with no wounds. Low CSF 5-HIAA concentrations were also correlated with greater risk-taking as determined byan analysis of leaping behaviors in the forest canopy. The ratio of long leaps (leaps that traversed the longest distances at dangerous heights) to all leaps was negatively correlated with CSF 5-HIAA concentrations. Conclusions: Adolescent male rhesus macaques with low CSF 5-HIAA concentrations are at risk for 1) exhibiting more violent forms of aggressive behavior and 2) loss of impulse control as evidenced by greater risk tracking during movement through the forest canopy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:20:22