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Titolo:
INCREASED GLUTAMINE-SYNTHETASE IMMUNOREACTIVITY IN EXPERIMENTAL PNEUMOCOCCAL MENINGITIS
Autore:
STRINGARIS AK; BRUCK W; TUMANI H; SCHMIDT H; NAU R;
Indirizzi:
UNIV GOTTINGEN,DEPT NEUROPATHOL,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY UNIV GOTTINGEN,DEPT NEUROPATHOL D-37075 GOTTINGEN GERMANY UNIV GOTTINGEN,DEPT NEUROL D-37075 GOTTINGEN GERMANY
Titolo Testata:
Acta Neuropathologica
fascicolo: 3, volume: 93, anno: 1997,
pagine: 215 - 218
SICI:
0001-6322(1997)93:3<215:IGIIEP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOPTOSIS; NECROSIS;
Keywords:
GLUTAMINE SYNTHETASE; IMMUNOHISTOCHEMISTRY; MENINGITIS; STREPTOCOCCUS PNEUMONIAE; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Stringaris et al., "INCREASED GLUTAMINE-SYNTHETASE IMMUNOREACTIVITY IN EXPERIMENTAL PNEUMOCOCCAL MENINGITIS", Acta Neuropathologica, 93(3), 1997, pp. 215-218

Abstract

Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFAP immunoreactivity remained unchanged. This may represent a protective mechanism for cortical neurons. The inability ofhippocampal GS to counteract the detrimental effects of glutamate maybe the cause of neuronal apoptosis observed in the dentate gyrus during meningitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:10:33