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Titolo:
CANCER-ASSOCIATED RETINOPATHY - THE CAR SYNDROME
Autore:
THIRKILL CE;
Indirizzi:
UNIV CALIF DAVIS,SACRAMENTO MED CTR,1603 ALHAMBRA BLVD SACRAMENTO CA 95817
Titolo Testata:
Neuro-ophthalmology
fascicolo: 5, volume: 14, anno: 1994,
pagine: 297 - 323
SICI:
0165-8107(1994)14:5<297:CR-TCS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEOPLASTIC CEREBELLAR DEGENERATION; SMALL-CELL-CARCINOMA; CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE UVEORETINITIS; COLLAGEN-INDUCED ARTHRITIS; EATON MYASTHENIC SYNDROME; S-ANTIGEN; PARANEOPLASTIC RETINOPATHY; MONOCLONAL-ANTIBODIES; LUNG-CARCINOMA;
Keywords:
PARANEOPLASIA; AUTOIMMUNE; RETINAL CAR ANTIGEN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
183
Recensione:
Indirizzi per estratti:
Citazione:
C.E. Thirkill, "CANCER-ASSOCIATED RETINOPATHY - THE CAR SYNDROME", Neuro-ophthalmology, 14(5), 1994, pp. 297-323

Abstract

Experimental data from basic research and experience accumulated fromthe clinical examination of patients who lose vision through the specific form of paraneoplastic retinopathy referred to as the CAR syndrome, indicates this form of vision loss results from autoimmune reactions. However, the eyes of CAR patients characteristically show little evidence of immune-cell influx and exhibit no resemblance to the acute intraocular reactions of uveitis or that induced experimentally in laboratory animals. Nevertheless, the CAR patient betrays evidence of immunologic involvement through the elaboration of autoantibodies reactivewith the 23 kDa retinal CAR antigen, located within the photoreceptors. The recent demonstration of the expression of this photoreceptor antigen by a culture of small cell carcinoma, has revealed an immunologic 'cancer connection' which may be responsible for the CAR patient's production of this unusual autoantibody response. CAR patients may therefore generate an autoimmune reaction against the 23 kDa CAR antigen in response to the stimulus of a neoplasm expressing the corresponding component as a cancer-associated antigen. The noninflammatory nature of this form of retinopathy suggests that, if autoimmune reactions are involved, they probably emanate from the humoral aspects of the immunesystem, possibly involving the autoantibodies which identify this syndrome. Consensus of opinion on the pathogenesis of CAR suggests that vision loss results as a cancer-evoked autoimmune reaction which may becontrolled through appropriate therapeutic measures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 10:00:33